Grant I S, Mackenzie N
Postgrad Med J. 1985;61 Suppl 3:133-7.
The effect of propofol, in the emulsion formulation, on post-anaesthetic recovery was studied in 80 patients anaesthetized using one of three different techniques. Propofol was administered to 20 day case patients for induction of anaesthesia, to 20 patients for induction and maintenance by intermittent bolus injection to supplement spinal blockade, and to 40 patients for induction and maintenance by continuous infusion with spontaneous ventilation. Its effects were compared with those of methohexitone (all three techniques) and thiopentone (day case study only). The assessment of post-operative recovery included measurement of the speed of immediate recovery, psychometric testing comprising choice reaction time and critical flicker fusion threshold and the incidence of post-operative sequelae. In all three techniques, propofol was associated with rapid and symptom-free recovery from anaesthesia. With the day case and infusion techniques immediate recovery was more rapid after propofol than after methohexitone and thiopentone. Recovery of psychomotor function was more rapid after propofol in the day case study. The frequency of sequelae such as nausea and vomiting (5% of cases), headache (1%) and confusion/restlessness (2.5%) was considerably lower overall after propofol and in each individual study than with the other agents.
在80例采用三种不同麻醉技术之一进行麻醉的患者中，研究了乳剂配方的丙泊酚对麻醉后恢复的影响。将丙泊酚给予20例日间手术患者用于诱导麻醉，给予20例患者通过间歇性推注进行诱导和维持以补充脊髓阻滞，给予40例患者通过持续输注并自主通气进行诱导和维持。将其效果与甲己炔巴比妥（所有三种技术）和硫喷妥钠（仅日间手术研究）的效果进行比较。术后恢复的评估包括测量即刻恢复速度、包括选择反应时间和临界闪烁融合阈值的心理测试以及术后后遗症的发生率。在所有三种技术中，丙泊酚均与麻醉后快速且无并发症的恢复相关。在日间手术和输注技术中，丙泊酚组的即刻恢复比甲己炔巴比妥和硫喷妥钠组更快。在日间手术研究中，丙泊酚组的精神运动功能恢复更快。总体而言，丙泊酚组以及各单项研究中，恶心和呕吐（5%的病例）、头痛（1%）和意识模糊/躁动（2.5%）等后遗症的发生率比其他药物组低得多。
