Internal Medicine, University of Missouri Kansas City, Kansas City, Missouri, USA.
Medicine, Section of Hematology and Oncology, University of Missouri Kansas City School of Medicine, Kansas City, Missouri, USA.
BMJ Case Rep. 2024 May 21;17(5):e256818. doi: 10.1136/bcr-2023-256818.
Vanishing bile duct syndrome is an uncommon condition characterised by the progressive loss and disappearance of bile ducts. It is an acquired form of cholestatic liver disease presenting with hepatic ductopenia (loss of >50% bile ducts in the portal areas). We present a case of vanishing bile duct syndrome as a presentation of Hodgkin's lymphoma who was treated with standard-of-care chemotherapy-doxorubicin, bleomycin, vinblastine and dacarbazine (along with brief administration of rituximab), which led to complete response and normalisation of liver function.
消失性胆管综合征是一种不常见的疾病，其特征为胆管进行性丧失和消失。它是一种获得性胆汁淤积性肝病，表现为肝内胆管减少（门脉区＞50%的胆管丧失）。我们报告一例以霍奇金淋巴瘤为表现的消失性胆管综合征，患者接受了标准治疗方案的化疗（多柔比星、博来霉素、长春碱和达卡巴嗪），并短暂给予利妥昔单抗治疗，这导致完全缓解和肝功能正常化。
