Office of Nutrition Research, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, MD, USA.
, Cary, NC, USA.
Metabolomics. 2024 May 21;20(3):60. doi: 10.1007/s11306-024-02111-4.
Metabolomic epidemiology studies are complex and require a broad array of domain expertise. Although many metabolite-phenotype associations have been identified; to date, few findings have been translated to the clinic. Bridging this gap requires understanding of both the underlying biology of these associations and their potential clinical implications, necessitating an interdisciplinary team approach. To address this need in metabolomic epidemiology, a workshop was held at Metabolomics 2023 in Niagara Falls, Ontario, Canada that highlighted the domain expertise needed to effectively conduct these studies -- biochemistry, clinical science, epidemiology, and assay development for biomarker validation -- and emphasized the role of interdisciplinary teams to move findings towards clinical translation.
代谢组学流行病学研究较为复杂,需要广泛的专业知识。虽然已经确定了许多代谢物-表型关联;但迄今为止,这些发现很少被转化为临床应用。要缩小这一差距,需要了解这些关联的基础生物学及其潜在的临床意义,这需要采用跨学科团队方法。为了满足代谢组学流行病学领域的这一需求,在加拿大安大略省尼亚加拉大瀑布举行的 2023 年代谢组学会议上举办了一次研讨会,强调了开展这些研究所需的专业知识领域——生物化学、临床科学、流行病学和生物标志物验证的检测开发——并强调了跨学科团队在将研究成果推向临床转化方面的作用。