Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun, 130000, Jilin, China.
Nutr Diabetes. 2024 May 21;14(1):31. doi: 10.1038/s41387-024-00291-5.
The purpose of this review is to investigate the relationship between gastrointestinal microbiome, obesity, and gestational diabetes mellitus (GDM) in an objective manner.
We conducted a thorough and comprehensive search of the English language literatures published in PubMed, Web of Science, and the Cochrane Library from the establishment of the library until 12 December 2023. Our search strategy included both keywords and free words searches, and we strictly applied inclusion and exclusion criteria. Meta-analyses and systematic reviews were prepared.
Six high-quality literature sources were identified for meta-analysis. However, after detailed study and analysis, a certain degree of heterogeneity was found, and the credibility of the combined analysis results was limited. Therefore, descriptive analyses were conducted. The dysbiosis of intestinal microbiome, specifically the ratio of Firmicutes/Bacteroides, is a significant factor in the development of metabolic diseases such as obesity and gestational diabetes. Patients with intestinal dysbiosis and obesity are at a higher risk of developing GDM.
During pregnancy, gastrointestinal microbiome disorders and obesity may contribute to the development of GDM, with all three factors influencing each other. This finding could aid in the diagnosis and management of patients with GDM through further research on their gastrointestinal microbiome.
本综述旨在客观地探讨胃肠道微生物组、肥胖与妊娠期糖尿病（GDM）之间的关系。
我们全面检索了 PubMed、Web of Science 和 Cochrane Library 中自建库至 2023 年 12 月 12 日发表的英文文献，检索策略包括关键词和自由词检索，并严格应用纳入和排除标准。对纳入的文献进行 Meta 分析和系统评价。
共纳入 6 篇高质量文献进行 Meta 分析，但经过详细研究和分析，发现存在一定程度的异质性，限制了合并分析结果的可信度，因此进行了描述性分析。肠道微生物组的失调，特别是厚壁菌门/拟杆菌门的比值，是肥胖和妊娠期糖尿病等代谢性疾病发展的重要因素。肠道失调和肥胖的患者发生 GDM 的风险更高。
在妊娠期间，胃肠道微生物组紊乱和肥胖可能导致 GDM 的发生，这三个因素相互影响。通过进一步研究 GDM 患者的胃肠道微生物组，可以帮助诊断和管理 GDM 患者。
