Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China.
Obesity (Silver Spring). 2022 Oct;30(10):2044-2054. doi: 10.1002/oby.23517. Epub 2022 Aug 31.
The study aimed to identify BMI-related lipids and to explore the role of lipids linking BMI and gestational diabetes mellitus (GDM).
Plasma lipidome, height, and weight were measured in early pregnancy among 1008 women. Pearson correlation analyses and least absolute shrinkage and selection operator regression (LASSO) were performed to identify BMI-associated lipids. Based on these lipids, a lipid score was created using LASSO, and its association with GDM risk was evaluated by conditional logistic regression. The causal relationships between BMI and lipids were tested by Mendelian randomization analysis with genotyping data. Mediation analysis was conducted to evaluate the mediating effect of lipids on the association of BMI with GDM.
Of 366 measured lipids, BMI was correlated with 28 lipids, which mainly belong to glycerophospholipids and glycerolipids. A total of 10 lipid species were associated with BMI, and a lipid score was established. A causal relationship between BMI and lysophosphatidylcholine 14:0 was observed. The lipid score was associated with a 1.69-fold increased risk of GDM per 1-point increment (95% CI: 1.33-2.15). Furthermore, BMI-associated lipids might explain 66.4% of the relationship between BMI and GDM.
Higher BMI in early pregnancy was associated with altered lipid metabolism that may contribute to the increased risk of GDM.
本研究旨在鉴定与 BMI 相关的脂质，并探讨脂质在 BMI 与妊娠期糖尿病（GDM）之间关联中的作用。
在 1008 名孕妇的早孕期测量了血浆脂质组、身高和体重。采用 Pearson 相关分析和最小绝对收缩和选择算子回归（LASSO）鉴定与 BMI 相关的脂质。基于这些脂质，使用 LASSO 构建了一个脂质评分，并通过条件逻辑回归评估其与 GDM 风险的关联。利用基因分型数据进行孟德尔随机化分析来检验 BMI 与脂质之间的因果关系。采用中介分析评估脂质在 BMI 与 GDM 关联中的中介作用。
在测量的 366 种脂质中，BMI 与 28 种脂质相关，这些脂质主要属于甘油磷脂和甘油三酯。共有 10 种脂质与 BMI 相关，并建立了一个脂质评分。观察到 BMI 与溶血磷脂酰胆碱 14:0 之间存在因果关系。脂质评分每增加 1 分，GDM 的风险增加 1.69 倍（95%CI：1.33-2.15）。此外，BMI 相关的脂质可能解释了 BMI 与 GDM 之间关系的 66.4%。
早孕期较高的 BMI 与脂质代谢改变有关，这可能导致 GDM 的风险增加。
