抗癫痫药物对癫痫患者的精神影响。
Psychiatric implications of anti-seizure medications in epileptic population.
机构信息
Pakistan Institute of Medical sciences, Islamabad, Pakistan.
出版信息
BMC Neurol. 2024 May 21;24(1):166. doi: 10.1186/s12883-024-03670-8.
BACKGROUND AND OBJECTIVE
Epilepsy is a prevalent neurological disorder that affects a significant number of individuals globally. This condition is associated with a high occurrence of psychiatric comorbidities, which can significantly affect the quality of life of individuals affected. The aim of this study was to investigate the association between antiseizure therapies and the likelihood of psychiatric comorbidities in individuals with epilepsy.
METHODOLOGY
Data for this study was gathered from the Neurology referral center in Islamabad, Pakistan. A standardized questionnaire was utilized to gather data from 120 individuals diagnosed with epilepsy. The survey consisted of inquiries regarding the management of seizures, the utilization of anti-seizure medications, and the presence of psychiatric comorbidities. The data was analyzed using the Statistical Package for the Social Sciences (SPSS).
RESULTS
The findings indicated that individuals who were using multiple antiseizure medications had a notably higher likelihood of having psychiatric comorbidities in comparison to those who were on mono therapy (p = 0.010). suggests that patients with unsuccessful seizure control are more probable to have psychiatric comorbidities as compared to those with good seizure control (p = 0.029).
CONCLUSION
To conclude poor seizure control and poly therapy are associated with increased risk of psychiatric comorbidities.
背景和目的
癫痫是一种常见的神经系统疾病，在全球范围内影响着大量人群。这种疾病与精神共病的发生率很高有关，这会显著影响受影响个体的生活质量。本研究旨在探讨抗癫痫治疗与癫痫患者发生精神共病的可能性之间的关系。
方法
本研究的数据来自巴基斯坦伊斯兰堡的神经科转诊中心。我们使用标准化问卷从 120 名被诊断患有癫痫的个体中收集数据。该调查包括关于癫痫发作管理、抗癫痫药物使用和精神共病存在情况的询问。使用社会科学统计软件包（SPSS）对数据进行分析。
结果
研究结果表明，与使用单药治疗的个体相比，使用多种抗癫痫药物的个体发生精神共病的可能性明显更高（p=0.010）。此外，那些癫痫控制不佳的患者比那些癫痫控制良好的患者更有可能发生精神共病（p=0.029）。
结论
总之，癫痫控制不佳和多药治疗与精神共病风险增加有关。
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