Hancke E, Jaursch J U, Voigt U
Zentralbl Chir. 1985;110(15):925-31.
The effect of perioperative antibiotics on septic complications in emergency bowel surgery was studied by reviewing the charts of patients. The rate of septic complications was essentially reduced in patients, who had received antibiotics pre-, intra- or immediately postoperatively compared with patients without any antibiotic medication (without antibiotics [n = 25] 6 abdominal wound infections, 5 lethal anastomotic disruptions, 2 urinary infections; with antibiotics [n = 24] 0 abdominal wound infections, 2 lethal anastomotic disruptions, 1 urinary and 1 pulmonary infections). Because of the significant reduction of abdominal wound infections which could be achieved in treating patients (X2 = 6,56; p less than 0,05) with antibiotics, these medicaments should be given in emergency bowel surgery with a further prospective controlled study being not necessary.
通过回顾患者病历,研究了围手术期使用抗生素对急诊肠道手术中感染性并发症的影响。与未使用任何抗生素药物的患者(未使用抗生素组[n = 25],6例腹部伤口感染,5例致命性吻合口破裂,2例泌尿系统感染)相比,术前、术中或术后立即接受抗生素治疗的患者感染性并发症发生率显著降低(使用抗生素组[n = 24],0例腹部伤口感染,2例致命性吻合口破裂,1例泌尿系统感染和1例肺部感染)。由于使用抗生素治疗患者可显著降低腹部伤口感染发生率(χ² = 6.56;p < 0.05),因此在急诊肠道手术中应使用这些药物,无需进一步进行前瞻性对照研究。