Winker H, Dortenmann J, Wittmann D H
Chirurg. 1983 Apr;54(4):272-7.
In a prospective randomized trial clinical results of orthograde bowel lavage alone (group I) versus combined bowel lavage and parenteral antibiotic prophylaxis with 4 gm Cefoxitin (group II) in two separate dosages (perioperative short-term-prophylaxis) are compared with regard to the reduction of septic complications after colorectal surgery. Septic wound complications were 11/27 = 41% in group I and 2/30 = 7% in group II. The rate of anastomotic leakages was significantly different in the two groups (5/27 in group I, 0 in group II). The monetary costs for given antibiotics and the duration of hospitalization were less in group II. Orthograde bowel lavage alone proved to be of no effect in reducing the rate of septic complications when used without antibiotic perioperative short-term-prophylaxis and therefore cannot be recommended to be used solely.
在一项前瞻性随机试验中，对单纯顺行肠道灌洗（第一组）与联合肠道灌洗及静脉注射4克头孢西丁进行围手术期短期预防（第二组）两种不同剂量方案在结直肠手术后减少感染并发症方面的临床结果进行了比较。第一组的感染性伤口并发症为11/27 = 41%，第二组为2/30 = 7%。两组的吻合口漏发生率有显著差异（第一组为5/27，第二组为0）。第二组使用的抗生素费用和住院时间较少。单纯顺行肠道灌洗在没有围手术期短期抗生素预防的情况下，在降低感染并发症发生率方面没有效果，因此不建议单独使用。
