Department of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Department of Anatomy, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Front Immunol. 2024 May 7;15:1393392. doi: 10.3389/fimmu.2024.1393392. eCollection 2024.
This review provides a comprehensive analysis of the critical role played by macrophages and their underlying mechanisms in the progression of diabetic cardiomyopathy (DCM). It begins by discussing the origins and diverse subtypes of macrophages, elucidating their spatial distribution and modes of intercellular communication, thereby emphasizing their significance in the pathogenesis of DCM. The review then delves into the intricate relationship between macrophages and the onset of DCM, particularly focusing on the epigenetic regulatory mechanisms employed by macrophages in the context of DCM condition. Additionally, the review discusses various therapeutic strategies aimed at targeting macrophages to manage DCM. It specifically highlights the potential of natural food components in alleviating diabetic microvascular complications and examines the modulatory effects of existing hypoglycemic drugs on macrophage activity. These findings, summarized in this review, not only provide fresh insights into the role of macrophages in diabetic microvascular complications but also offer valuable guidance for future therapeutic research and interventions in this field.
这篇综述全面分析了巨噬细胞及其潜在机制在糖尿病心肌病（DCM）进展中的关键作用。它首先讨论了巨噬细胞的起源和多种亚型，阐明了它们的空间分布和细胞间通讯方式，从而强调了它们在 DCM 发病机制中的重要性。然后，该综述深入探讨了巨噬细胞与 DCM 发病之间的复杂关系，特别是重点研究了巨噬细胞在 DCM 条件下采用的表观遗传调控机制。此外，该综述还讨论了各种旨在靶向巨噬细胞以治疗 DCM 的治疗策略。它特别强调了天然食物成分在缓解糖尿病微血管并发症方面的潜力，并研究了现有降血糖药物对巨噬细胞活性的调节作用。这些研究结果总结在这篇综述中，不仅为巨噬细胞在糖尿病微血管并发症中的作用提供了新的见解，也为该领域未来的治疗研究和干预提供了有价值的指导。
