Synkowski D R, Schuster P, Orlando J C
Br J Dermatol. 1985 Oct;113(4):441-6. doi: 10.1111/j.1365-2133.1985.tb02358.x.
A semi-quantitative, immunoperoxidase monoclonal antibody technique was used to study the mononuclear cells surrounding 32 basal cell carcinoma specimens from 30 patients. Tumours were analysed in subgroups based on recurrence, size and ulceration. T cell counts were high (greater than 3 out of 4) for all groups while T helper/inducer and T suppressor/cytotoxic cell counts were equal (approx. 2). Macrophage counts were low for all groups, about I X 2, while B cell and Ia positive cell counts were high (greater than 3). T/B cell and T helper/suppressor cell ratios approached one for the tumours as a whole as well as the sub-groups. The relative importance and contribution of cell mediated vs. humoral immunity in keeping basal cell carcinomas in check is discussed.
采用半定量免疫过氧化物酶单克隆抗体技术，对30例患者的32个基底细胞癌标本周围的单核细胞进行了研究。根据复发情况、大小和溃疡情况对肿瘤进行亚组分析。所有组的T细胞计数都很高（4个中有3个以上），而辅助性/诱导性T细胞和抑制性/细胞毒性T细胞计数相等（约为2）。所有组的巨噬细胞计数都很低，约为1×2，而B细胞和Ia阳性细胞计数很高（大于3）。整个肿瘤及其亚组的T/B细胞和辅助性/抑制性T细胞比值接近1。讨论了细胞介导免疫与体液免疫在控制基底细胞癌方面的相对重要性和贡献。
