基底细胞癌和鳞状细胞癌患者的细胞介导免疫

Cell-mediated immunity in patients with basal and squamous cell skin cancer.

作者信息

Weimar V M, Ceilley R I, Goeken J A

出版信息

J Am Acad Dermatol. 1980 Feb;2(2):143-7. doi: 10.1016/s0190-9622(80)80393-8.

Abstract

T and B lymphocyte levels were normal in fifty patients with basal and squamous cell skin cancer. Patients with basal cell carcinomas and small squamous cell carcinomas reacted normally to intradermal antigens and to dinitrochlorobenzene (DNCB). However, patients with large (greater than 3 cm) squamous cell carcinomas appeared to have defective systemic cell-mediated immunity because only 33% of them reacted to at least one intradermal antigen, and only 67% could be sensitized to DNCB. Presently, it is unknown whether this defect is related to the occurrence or behavior of squamous cell carcinoma.

摘要

50例基底细胞癌和鳞状细胞皮肤癌患者的T淋巴细胞和B淋巴细胞水平正常。基底细胞癌和小鳞状细胞癌患者对皮内抗原和二硝基氯苯（DNCB）反应正常。然而，患有大（大于3厘米）鳞状细胞癌的患者似乎存在全身性细胞介导免疫缺陷，因为其中只有33%的患者对至少一种皮内抗原产生反应，只有67%的患者能够被DNCB致敏。目前，尚不清楚这种缺陷是否与鳞状细胞癌的发生或行为有关。