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实体瘤的过继性细胞疗法:黑色素瘤的现状及下一代疗法

Adoptive Cell Therapy for Solid Tumors: Current Status in Melanoma and Next-Generation Therapies.

作者信息

Haanen John, Los Christy, Phan Giao Q, Betof Warner Allison

机构信息

Division of Medical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.

Department of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands.

出版信息

Am Soc Clin Oncol Educ Book. 2024 Jun;44(3):e431608. doi: 10.1200/EDBK_431608.

DOI:10.1200/EDBK_431608
PMID:38776509
Abstract

Lifileucel or TIL has recently been FDA approved for metastatic melanoma patients as first cell therapy for a solid tumor. We discuss roll-out of TIL as new SOC and other upcoming new cell therapies.

摘要

利菲鲁塞(Lifileucel)或肿瘤浸润淋巴细胞(TIL)最近已获得美国食品药品监督管理局(FDA)批准,用于转移性黑色素瘤患者,作为实体瘤的首个细胞疗法。我们讨论了将肿瘤浸润淋巴细胞作为新的标准治疗方案(SOC)的推广以及其他即将出现的新细胞疗法。

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Adoptive Cell Therapy for Solid Tumors: Current Status in Melanoma and Next-Generation Therapies.实体瘤的过继性细胞疗法:黑色素瘤的现状及下一代疗法
Am Soc Clin Oncol Educ Book. 2024 Jun;44(3):e431608. doi: 10.1200/EDBK_431608.
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Lifileucel: the first cellular therapy approved for solid tumours.利弗利塞细胞:首个获批用于实体瘤的细胞疗法。
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Efficacy and safety of lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in patients with advanced melanoma after progression on immune checkpoint inhibitors and targeted therapies: pooled analysis of consecutive cohorts of the C-144-01 study.在免疫检查点抑制剂和靶向治疗进展后,晚期黑色素瘤患者单次自体肿瘤浸润淋巴细胞(TIL)细胞治疗 lifileucel 的疗效和安全性:C-144-01 研究连续队列的汇总分析。
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Clinical responses in a phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients.Ⅱ期研究中过继转移短期培养的肿瘤浸润淋巴细胞治疗转移性黑色素瘤患者的临床反应。
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Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2.自体肿瘤浸润淋巴细胞和低剂量白细胞介素-2过继细胞疗法治疗转移性黑色素瘤的 II 期临床试验。
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Focus on adoptive T cell transfer trials in melanoma.关注黑色素瘤中过继性T细胞转移试验。
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