Institute of Plant Biochemistry and Photosynthesis (IBVF-CSIC-US), Avenida Américo Vespucio 49, 41092, Seville, Spain.
Institute of Plant Biochemistry and Photosynthesis (IBVF-CSIC-US), Avenida Américo Vespucio 49, 41092, Seville, Spain.
Curr Opin Plant Biol. 2024 Aug;80:102553. doi: 10.1016/j.pbi.2024.102553. Epub 2024 May 21.
Polycomb Group (PcG) histone-modifying system is key in maintaining gene repression, providing a mitotically heritable cellular memory. Nevertheless, to allow plants to transition through distinct transcriptional programs during development or to respond to external cues, PcG-mediated repression requires reversibility. Several data suggest that the dynamics of PcG marks may vary considerably in different cell contexts; however, how PcG marks are established, maintained, or removed in each case is far from clear. In this review, we survey the knowns and unknowns of the molecular mechanisms underlying the maintenance or turnover of PcG marks in different cell stages.
多梳组 (PcG) 组蛋白修饰系统是维持基因沉默的关键，为细胞提供有丝分裂遗传的记忆。然而，为了使植物在发育过程中通过不同的转录程序转变，或对外部信号做出反应，PcG 介导的抑制需要可逆性。有几项数据表明，PcG 标记的动态在不同的细胞环境中可能有很大的差异；然而，在每种情况下，PcG 标记是如何建立、维持或去除的，目前还远不清楚。在这篇综述中，我们调查了不同细胞阶段 PcG 标记维持或周转的分子机制的已知和未知。
