Förderer Alexander, Zhou Yue, Turck Franziska
Max Planck Institute for Plant Breeding Research, Department Plant Developmental Biology, Carl von Linne Weg 10, 50829 Köln, Germany.
Max Planck Institute for Plant Breeding Research, Department Plant Developmental Biology, Carl von Linne Weg 10, 50829 Köln, Germany.
Curr Opin Plant Biol. 2016 Feb;29:169-78. doi: 10.1016/j.pbi.2015.11.010. Epub 2016 Jan 28.
Polycomb group (PcG) proteins form distinct complexes that modify chromatin by histone H3 methylation and H2A mono-ubiquitination leading to chromatin compaction and epigenetic repression of target genes. A network of PcG protein complexes, associated partners and antagonistically acting chromatin modifiers is essential to regulate developmental transitions and cell fate in all multicellular eukaryotes. In this review, we discuss insights on the subfunctionalization of PcG complexes and their modes of recruitment to target sites based on data from the model organism Arabidopsis thaliana.
多梳蛋白家族（PcG）形成不同的复合物，通过组蛋白H3甲基化和H2A单泛素化修饰染色质，导致染色质压缩和靶基因的表观遗传抑制。PcG蛋白复合物、相关伴侣蛋白和起拮抗作用的染色质修饰因子网络对于调节所有多细胞真核生物的发育转变和细胞命运至关重要。在这篇综述中，我们基于模式生物拟南芥的数据，讨论了关于PcG复合物亚功能化及其募集到靶位点的模式的见解。
