Dykewicz M S, McGrath K G, Harris K E, Patterson R
Int Arch Allergy Appl Immunol. 1985;78(4):386-90. doi: 10.1159/000233918.
Streptokinase is used worldwide as a thrombolytic agent. Allergic reactions to streptokinase have been reported, but the immunologic mechanisms have not been well characterized. To develop a canine model of streptokinase immune responses analogous to human responses, four dogs received intravenous streptokinase infusions. Significant rises in IgG, IgA and IgM antibody levels occurred after streptokinase administration in three of four dogs; a fourth dog developed significant increases in IgG and IgA antibody levels. Two dogs developed immediate-type cutaneous hypersensitivity to streptokinase. One dog developed subacute dermatitis with eosinophilic infiltrates which was possibly a manifestation of an allergic reaction to streptokinase.
链激酶在全球范围内被用作溶栓剂。已有链激酶过敏反应的报道，但免疫机制尚未完全明确。为建立一种类似于人类反应的链激酶免疫反应犬模型，对四只犬进行了静脉注射链激酶。四只犬中有三只在注射链激酶后IgG、IgA和IgM抗体水平显著升高；第四只犬的IgG和IgA抗体水平显著增加。两只犬对链激酶产生速发型皮肤超敏反应。一只犬出现伴有嗜酸性粒细胞浸润的亚急性皮炎，这可能是对链激酶过敏反应的一种表现。
