Shakib F
Midlands Asthma and Allergy Research Association, Derby, United Kingdom.
N Engl Reg Allergy Proc. 1988 Jan-Feb;9(1):35-42. doi: 10.2500/108854188778984482.
Although IgG4 (or at least one of its variants) does have receptors on basophils, this IgG subclass apparently cannot mediate an allergen-triggered release of mediators. Evidence is now available to suggest that IgG4-bearing basophils can be "fired off" to release histamine with an IgM anti-IgG which is frequently found in atopic patients. If an autoimmune process of the kind described here can contribute to the pathological changes in atopic disorder, then a whole new approach to the diagnosis and treatment of allergic disease must be considered.
尽管IgG4（或其至少一种变体）确实在嗜碱性粒细胞上有受体，但这种IgG亚类显然无法介导变应原触发的介质释放。现在有证据表明，携带IgG4的嗜碱性粒细胞可以被一种在特应性患者中经常发现的IgM抗IgG“激发”而释放组胺。如果这里描述的这种自身免疫过程会导致特应性疾病的病理变化，那么就必须考虑一种全新的过敏性疾病诊断和治疗方法。
