急性非动脉炎性前部缺血性视神经病变治疗证据综述
Review of evidence for treatments of acute non arteritic anterior ischemic optic neuropathy.
作者信息
Parthasarathi Pooja, Moss Heather E
机构信息
Department of Ophthalmology, Stanford University, Palo Alto, CA, 94303, USA.
Department of Neurology & Neurological Sciences, Stanford University, Palo Alto, CA, 94303, USA.
出版信息
Eye (Lond). 2024 Aug;38(12):2267-2278. doi: 10.1038/s41433-024-03136-8. Epub 2024 May 22.
OBJECTIVE
To review treatment modalities that have been studied in acute non arteritic anterior ischemic optic neuropathy (NAION).
METHODS
We performed a comprehensive literature search of English language publications in the last 5 years, with human species and NAION. Articles were reviewed to identify those that described original research on treatment of acute NAION. Study type, setting, duration, interventions, and results were extracted and articles were reviewed for biases and limitations.
RESULTS
We identified 22 kinds of treatment varying by compound and modality. These include topical, intravitreal, and systemic drugs as well as surgical approaches. Evidence for efficacy ranges from expert opinion to randomized control trials.
CONCLUSIONS
Although several treatments are utilized in practice, none of these have high quality evidence of efficacy to improve visual outcomes. Continued collaborative research is necessary to complete high quality studies in order identify effective therapies for this rare and blinding disease.
目的
回顾已在急性非动脉炎性前部缺血性视神经病变（NAION）中进行研究的治疗方式。
方法
我们对过去5年发表的英文文献进行了全面检索，检索词为人类和NAION。对文章进行审查，以确定那些描述急性NAION治疗的原始研究。提取研究类型、研究背景、持续时间、干预措施和结果，并对文章的偏倚和局限性进行审查。
结果
我们确定了22种因化合物和治疗方式而异的治疗方法。这些包括局部、玻璃体内和全身用药以及手术方法。疗效证据的范围从专家意见到随机对照试验。
结论
虽然在实践中使用了几种治疗方法，但这些方法均没有高质量的证据证明其能有效改善视力。需要持续开展合作研究以完成高质量研究，从而确定针对这种罕见致盲疾病的有效治疗方法。
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