Hu Y T, Xiao Q, Ding K F, Zheng S
Department of Colorectal Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine; Key Laboratory of Cancer Prevention and Intervention, Ministry of Education; Zhejiang Provincial Clinical Medical Research Center for Malignant Tumors, Hangzhou 310009, China.
Department of Colorectal Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine; Key Laboratory of Cancer Prevention and Intervention, Ministry of Education; Zhejiang Provincial Clinical Medical Research Center for Malignant Tumors, Hangzhou 310009, China Center for Medical Research and Innovation in Digestive System Tumors, Ministry of Education, Hangzhou 310058, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2024 May 25;27(5):430-435. doi: 10.3760/cma.j.cn441530-20240305-00086.
The incidence and mortality rates of early-onset colorectal cancer (EOCRC) among people under 50 years old are showing an upward trend. Although traditional epidemiological studies have conducted relatively deep research and screened out environmental factors related to EOCRC, our understanding of the causes, mechanisms, and treatment of this disease is still far from sufficient. In this review, we clarify the current progress of EOCRC, with a particular focus on epidemiology, screening status, clinical symptoms, and prognosis. This provides new evidence for secondary prevention, including precision screening, and offers new ideas for improving the diagnosis and treatment of EOCRC.
50岁以下人群中早发性结直肠癌（EOCRC）的发病率和死亡率呈上升趋势。尽管传统流行病学研究已进行了较为深入的研究，并筛选出了与EOCRC相关的环境因素，但我们对这种疾病的病因、机制和治疗的了解仍远远不够。在本综述中，我们阐明了EOCRC的当前进展，特别关注流行病学、筛查状况、临床症状和预后。这为二级预防（包括精准筛查）提供了新证据，并为改善EOCRC的诊断和治疗提供了新思路。
