Li Y Q, Li X X
Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2024 May 25;27(5):441-446. doi: 10.3760/cma.j.cn441530-20240204-00057.
In recent years, the incidence rate of early-onset colorectal cancer (EOCRC) continues to rise, but its pathogenesis is still unclear. EOCRC is different from late-onset colorectal cancer in terms of the clinical and molecular pathological features, but their treatment strategies are the same, due to a lack of specific guidelines of screening, diagnosis and treatment for EOCRC. This article summarizes the research progress of epidemiological characteristics, risk factors, clinical features, molecular pathological features, pathogenesis, and prevention and screening strategies for EOCRC, in order to provide theoretical basis for the clinical treatment of patients with EOCRC.
近年来，早发性结直肠癌（EOCRC）的发病率持续上升，但其发病机制仍不清楚。EOCRC在临床和分子病理特征方面与晚发性结直肠癌不同，但由于缺乏针对EOCRC的筛查、诊断和治疗的具体指南，它们的治疗策略是相同的。本文总结了EOCRC的流行病学特征、危险因素、临床特征、分子病理特征、发病机制以及预防和筛查策略的研究进展，以期为EOCRC患者的临床治疗提供理论依据。
