Al-Nerabieah Zuhair, AlKhouli Muaaz, Dashash Mayssoon
Pediatric Dentistry, Damascus University, Damascus, Damascus Governorate, Syria.
F1000Res. 2024 May 7;12:1052. doi: 10.12688/f1000research.136653.2. eCollection 2023.
This randomized controlled trial aimed to compare the efficacy of silver diamine fluoride (SDF) and casein phosphopeptide-amorphous calcium phosphate fluoride varnish (CPP-ACPFV) in preventing caries development, enamel breakdown, and sensitivity on molars affected by molar incisor hypomineralization (MIH) in children.
A total of 100 children aged 6 to 9 years were enrolled in the study with two contralateral permanent molars mildly affected by MIH. Affected molars were randomly and equally assigned to receive either SDF or CPP-ACPFV treatment. The interventions were applied at four different time points (baseline, 3, 6, 9 months), and the incidence of caries, caries progression, enamel breakdown, and sensitivity were assessed.
The findings of this study revealed significant differences in the incidence of caries between the groups treated with SDF and CPP-ACPFV ( -value < 0.05). Similarly, there was a significant difference in caries progression between the two groups ( -value < 0.05). However, no significant differences were observed in enamel breakdown scores between the treatment groups, as the majority of teeth in both groups exhibited a score of 0. Furthermore, there were no significant differences in sensitivity between the treatment groups throughout the study period.
In conclusion, the results of this study provide evidence that molars treated with SDF demonstrated a lower incidence of caries and a higher rate of caries arrest compared to those treated with CPP-ACPFV. Both interventions showed promise in preventing enamel breakdown and improving sensitivity. These findings highlight the potential of SDF and CPP-ACPFV as effective treatments for caries prevention and management, emphasizing the importance of early intervention and appropriate dental care strategies in maintaining oral health.
ISRCTN54243749 (13/01/2022).
这项随机对照试验旨在比较氟化亚锡（SDF）和酪蛋白磷酸肽 - 无定形磷酸钙氟化物漆（CPP - ACPFV）在预防儿童磨牙低矿化（MIH）患牙龋齿发展、牙釉质破坏和敏感方面的疗效。
共有100名6至9岁的儿童参与研究，其两颗对侧恒磨牙轻度受MIH影响。将患牙随机且平均分配接受SDF或CPP - ACPFV治疗。干预措施在四个不同时间点（基线、3个月、6个月、9个月）实施，并评估龋齿发病率、龋齿进展、牙釉质破坏和敏感情况。
本研究结果显示，接受SDF和CPP - ACPFV治疗的组间龋齿发病率存在显著差异（P值<0.05）。同样，两组间龋齿进展也存在显著差异（P值<0.05）。然而，治疗组间牙釉质破坏评分无显著差异，因为两组中的大多数牙齿评分为0。此外，在整个研究期间，治疗组间敏感情况无显著差异。
总之，本研究结果表明，与接受CPP - ACPFV治疗的磨牙相比，接受SDF治疗的磨牙龋齿发病率更低，龋齿停止发展的比率更高。两种干预措施在预防牙釉质破坏和改善敏感方面均显示出前景。这些发现突出了SDF和CPP - ACPFV作为预防和管理龋齿的有效治疗方法的潜力，强调了早期干预和适当的口腔护理策略在维持口腔健康方面的重要性。
ISRCTN54243749（2022年1月13日）。
