考虑异质性癌细胞的模型对立体定向体部放射治疗非小细胞肺癌肿瘤控制概率预测的通用性评估
Generality Assessment of a Model Considering Heterogeneous Cancer Cells for Predicting Tumor Control Probability for Stereotactic Body Radiation Therapy Against Non-Small Cell Lung Cancer.
作者信息
Saga Ryo, Matsuya Yusuke, Obara Hideki, Komai Fumio, Yoshino Hironori, Aoki Masahiko, Hosokawa Yoichiro
机构信息
Department of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.
Nuclear Science and Engineering Center, Research Group for Radiation Transport Analysis, Japan Atomic Energy Agency, Tokai, Japan.
出版信息
Adv Radiat Oncol. 2024 Jan 1;9(4):101437. doi: 10.1016/j.adro.2023.101437. eCollection 2024 Apr.
The generality of a model for predicting tumor control probability from in vitro clonogenic survival considering of cancer stem-like cells, the so-called integrated microdosimetric-kinetic model, is presented by comparing the model to public data on stereotactic body radiation therapy for non-small cell lung cancer cells.
通过将预测肿瘤控制概率的模型（即所谓的综合微剂量动力学模型，该模型从考虑癌症干细胞的体外克隆形成存活情况出发）与非小细胞肺癌细胞立体定向体部放射治疗的公开数据进行比较，展示了该模型的通用性。
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