Setor de Reprodução Humana, Departamento de Ginecologia e Obstetrícia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil,
Instituto Federal de São Paulo, campus Jacareí, Jacareí, SP, Brasil.
Arch Endocrinol Metab. 2023 May 25;67(5):e000627. doi: 10.20945/2359-3997000000627.
This study aimed to determine the differences in body fat distribution and central obesity indicators using dual-energy X-ray absorptiometry (DXA), adiposity indices, and anthropometric indices between women with and without polycystic ovary syndrome (PCOS).
Clinical and laboratory examination history, including transvaginal ultrasound, fasting blood samples, anthropometric measurements, and DXA scans were conducted in 179 women with PCOS (PCOS group) and 100 without PCOS (non-PCOS group). The volunteers were grouped by body mass index (BMI): normal (18-24.9 kg/m), overweight (25-29.9 kg/m), or obese (>30 kg/m). The visceral adiposity index (VAI) and lipid accumulation product (LAP) were calculated, regions of interest (ROIs) were determined, and the fat mass index (FMI) was calculated using DXA.
VAI, LAP, ROIs, FMI, and adiposity indices by DXA were higher in women with PCOS and normal BMI. In both PCOS and non-PCOS groups, the ROIs progressively increased from normal BMI to overweight and obese, and from overweight to obese. Obese women with PCOS showed high trunk fat mass. However, obesity was not able to modify these trunk/periphery fat ratios in PCOS from overweight to higher BMI. These variables were associated with the incidence of PCOS.
In women with PCOS and normal BMI, both DXA and the adiposity indices, VAI and LAP, are more sensitive methods to evaluate total body fat and fat accumulation in the central abdominal region. It was also observed that as BMI increased, the differences in measurements between women with and without PCOS decreased.
本研究旨在通过双能 X 射线吸收法（DXA）、肥胖指数和人体测量指数，比较多囊卵巢综合征（PCOS）患者和非 PCOS 患者的体脂分布和中心性肥胖指标的差异。
对 179 例 PCOS 患者（PCOS 组）和 100 例非 PCOS 患者（非 PCOS 组）进行了临床和实验室检查史，包括经阴道超声、空腹血样、人体测量和 DXA 扫描。志愿者按体重指数（BMI）分组：正常（18-24.9kg/m²）、超重（25-29.9kg/m²）或肥胖（>30kg/m²）。计算了内脏脂肪指数（VAI）和脂积指数（LAP），确定了感兴趣区域（ROI），并使用 DXA 计算了脂肪质量指数（FMI）。
PCOS 且 BMI 正常的女性的 VAI、LAP、ROI、FMI 和 DXA 肥胖指数较高。在 PCOS 和非 PCOS 组中，ROI 从正常 BMI 到超重和肥胖、从超重到肥胖逐渐增加。肥胖的 PCOS 女性表现出高躯干脂肪量。然而，肥胖并不能改变 PCOS 从超重到更高 BMI 时躯干/外周脂肪比。这些变量与 PCOS 的发生有关。
在 PCOS 且 BMI 正常的女性中，DXA 和肥胖指数、VAI 和 LAP 都是更敏感的方法，可以评估全身脂肪和中央腹部区域的脂肪堆积。还观察到，随着 BMI 的增加，PCOS 患者和非 PCOS 患者之间的测量值差异减小。
