Liu Chunhong, Yan Zheng, Zhang Xiaohai, Xia Taibao, Ashaolu Joseph Opeoluwa, Olatunji Opeyemi Joshua, Ashaolu Tolulope Joshua
Second People's Hospital of Wuhu City, 241001, Anhui, China.
Department of Public Health, Faculty of Basic Medical Sciences, Redeemers University, PMB 230, Ede, Osun State, Nigeria.
Heliyon. 2024 May 11;10(10):e31104. doi: 10.1016/j.heliyon.2024.e31104. eCollection 2024 May 30.
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the joints of the human body and is projected to have a prevalence age-standardized rate of 1.5 million new cases worldwide by 2030. Several conventional and non-conventional preventive and therapeutic interventions have been suggested but they have their side effects including nausea, abdominal pain, liver damage, ulcers, heightened blood pressure, coagulation, and bleeding. Interestingly, several food-derived peptides (FDPs) from both plant and animal sources are increasingly gaining a reputation for their potential in the management or therapy of RA with little or no side effects. In this review, the concept of inflammation, its major types (acute and chronic), and RA identified as a chronic type were discussed based on its pathogenesis and pathophysiology. The conventional treatment options for RA were briefly outlined as the backdrop of introducing the FDPs that potentiate therapeutic effects in the management of RA.
类风湿性关节炎（RA）是一种慢性炎症性自身免疫性疾病，会影响人体关节，预计到2030年，全球年龄标准化患病率将达150万新病例。已经提出了几种传统和非常规的预防和治疗干预措施，但它们都有副作用，包括恶心、腹痛、肝损伤、溃疡、血压升高、凝血和出血。有趣的是，几种来自动物和植物来源的食物衍生肽（FDP）因其在RA管理或治疗中的潜力而越来越受到关注，且几乎没有副作用。在这篇综述中，基于其发病机制和病理生理学，讨论了炎症的概念、其主要类型（急性和慢性）以及被确定为慢性类型的RA。作为引入在RA管理中增强治疗效果的FDP的背景，简要概述了RA的传统治疗选择。
