Wu Xinyuan, Yu Xiaomin, Chen Cheng, Chen Chenlu, Wang Yuxin, Su Dongyan, Zhu Liqing
School & Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Front Oncol. 2024 May 8;14:1393599. doi: 10.3389/fonc.2024.1393599. eCollection 2024.
Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.
血浆纤维蛋白原（Fg）水平升高一直与各种肿瘤患者队列的不良预后相关。在肿瘤微环境中，一直观察到Fg的异常沉积和表达，它与多种细胞受体相互作用，从而强化了其作为炎症过程调节因子的作用。具体而言，Fg可刺激和募集免疫细胞及促炎细胞因子，从而促进肿瘤进展。此外，Fg及其片段对肿瘤血管生成具有双重作用。值得注意的是，Fg还通过依赖血小板和不依赖血小板的机制促进肿瘤迁移。最近的研究揭示了受Fg影响的几种肿瘤相关信号通路。本综述全面总结了Fg在肿瘤生物学中的复杂参与情况，阐明了其多方面的作用及潜在机制。
