Department of Industrial Biotechnology, Faculty of Biotechnology, University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania.
Department of Biotechnology, Centre of Bioanalysis, National Institute of Research and Development for Biological Sciences, Bucharest, Romania.
Curr Vasc Pharmacol. 2024;22(5):365-374. doi: 10.2174/0115701611290537240509061549.
Targeting gut dysbiosis to treat chronic diseases or to alleviate the symptoms is a new direction for medical adjuvant therapies. Recently, postbiotics have received considerable attention as they are non-viable probiotic preparations that confer various health benefits to the host without the safety problems associated with using live microbial cells.
The aim of the study is to obtain selenium (Se) and zinc (Zn) enriched postbiotic biomass and to analyze its modulation effect because these minerals play an important role in reducing gut dysbiosis linked to cardiovascular (CV) diseases.
The effect of the and Se/Zn enriched yeast postbiotics on CV microbial fingerprint was studied using the gastrointestinal system (GIS 1) and analyzed by microbiological, chemical, and qPCR methods.
There was a 2.2 log CFU/mL increase in the total bacterial load after SeZn postbiotic treatment and in the qPCR counts of Firmicutes phyla for both treatments. Beneficial taxa, spp. and spp., as well as spp. were up to 1.5 log higher after mineral- enriched postbiotic application, while the acetic acid level increased.
These preliminary studies highlight the therapeutic potential of using Se/Zn enriched yeast postbiotics as adjuvants for clinical treatments of CV diseases.
针对肠道菌群失调来治疗慢性疾病或减轻症状是医学辅助治疗的一个新方向。最近，后生元作为非活性益生菌制剂受到了相当多的关注，因为它们可以为宿主带来各种健康益处，而不会产生使用活菌细胞相关的安全问题。
本研究旨在获得富含硒（Se）和锌（Zn）的后生元生物质，并分析其调节作用，因为这些矿物质在减少与心血管（CV）疾病相关的肠道菌群失调方面起着重要作用。
使用胃肠道系统（GIS 1）研究和分析富含 Se/Zn 的酵母后生元对 CV 微生物指纹图谱的影响，采用微生物学、化学和 qPCR 方法进行分析。
在后生元处理后，总细菌负荷增加了 2.2 个对数 CFU/mL，两种处理后厚壁菌门的 qPCR 计数也增加了。有益菌属，如 spp. 和 spp.，以及 spp.在矿物质富集后生元应用后增加了 1.5 个对数，而乙酸水平增加。
这些初步研究强调了使用富含 Se/Zn 的酵母后生元作为 CV 疾病临床治疗辅助剂的治疗潜力。
