GG and supplementation exert protective effects on human gut microbiome following antibiotic administration .

Antibiotic-induced dysbiosis of the microbial community has been associated with several gastrointestinal symptoms. The impact of repeated administration of GG (CNCM-I-4798) (formerly known as GG), (CNCM-I-1079) and their combination (associated in Smebiocta/Smectaflora Protect®) in supporting recovery of gut microbiota functionality and composition during and following amoxicillin:clavulanic acid administration was evaluated . Antibiotic dosage negatively affected SCFA production, coinciding with detrimental effects on and spp. in the simulated proximal colon, while was significantly reduced in the distal colon. GG and were able to thrive in both colon regions upon dosing, with even showing protective effects on the survival of GG during antibiotic administration. The impact of the probiotic strains on microbiome recovery revealed that supplementation with GG and/or resulted in a stimulating effect on the most abundant bacterial groups within the bacterial community of each donor. For one of the donors tested, co-dosing of GG and resulted in superior short-chain fatty acid recovery accompanied by a stronger increase in abundance of . Overall, the current study provides first evidence that combined supplementation of GG and might be an interesting candidate in limiting detrimental effects of amoxicillin:clavulanic acid on the human gut microbiome, though further studies are warranted to confirm these findings.