黑色素瘤患者的人类白细胞抗原（HLA）和DR抗原频率：与疾病预后的可能关系。

HLA and DR antigen frequencies in melanoma patients: possible relation to disease prognosis.

作者信息

Pollack M S, Livingston P O

出版信息

Tissue Antigens. 1985 Oct;26(4):262-5. doi: 10.1111/j.1399-0039.1985.tb00970.x.

DOI:10.1111/j.1399-0039.1985.tb00970.x

Abstract

The frequency of HLA-DR5 was significantly increased in a large group of malignant melanoma patients (33.7% vs 20.5% for controls). The subgroup of patients with poor prognosis showed both a DR5 increase and a relative decrease in DR1. Although none of these differences was significant after correction for the number of antigens tested, similar findings have been made for other malignancies and further studies should be encouraged.

摘要

在一大群恶性黑色素瘤患者中，HLA - DR5的频率显著增加（对照组为20.5%，患者组为33.7%）。预后较差的患者亚组显示DR5增加且DR1相对减少。尽管在校正所检测抗原数量后，这些差异均无统计学意义，但其他恶性肿瘤也有类似发现，因此应鼓励进一步研究。