Black C M, Welsh K I, Maddison P J, Jayson M I, Bernstein R M
Br J Rheumatol. 1984 Nov;23(4):267-71. doi: 10.1093/rheumatology/23.4.267.
The HLA antigens were determined in 54 Caucasoid patients with scleroderma (ARA criteria). All were assessed for extent of skin and organ involvement, anticentromere (ACA), and scleroderma 70 (Scl 70) antibodies. The antigens DR1, DR3 and DR5 were raised in the patient group, and DR2 was lowered. Of these only the increase in DR5 was significant (chi 2 = 5.2; p = 0.02). The increased frequency of DR3 was attributable to a rise in the A1, B8, DR3 haplotype (chi 2 = 3.9; p = 0.05). Patients with non-diffuse disease showed a significant increase in the DR1 and DR5 antigens (chi 2 = 3.7, p = 0.05; chi 2 = 8.0, p = 0.01). No association was found between the HLA antigens and specific organ involvement. Anticentromere antibodies were present in 15 of the HLA-DR typed patients. Thirteen of these 15 patients were either DR1 or DR5. No relationship was found between the frequencies of HLA antigens and anti-Scl 70 antibodies.
对54例符合美国风湿病学会（ARA）标准的白种人硬皮病患者进行了HLA抗原检测。所有患者均评估了皮肤和器官受累程度、抗着丝点抗体（ACA）和硬皮病70抗体（Scl 70）。患者组中DR1、DR3和DR5抗原升高，DR2抗原降低。其中只有DR5的升高具有统计学意义（χ2 = 5.2；p = 0.02）。DR3频率的增加归因于A1、B8、DR3单倍型的升高（χ2 = 3.9；p = 0.05）。非弥漫性疾病患者的DR1和DR5抗原显著增加（χ2 = 3.7，p = 0.05；χ2 = 8.0，p = 0.01）。未发现HLA抗原与特定器官受累之间存在关联。在进行了HLA - DR分型的患者中，15例存在抗着丝点抗体。这15例患者中有13例为DR1或DR5。未发现HLA抗原频率与抗Scl 70抗体之间存在关系。
