Linkage disequilibrium between the HLA-B14 subdivisions and HLA-A, DR and properdin factor B alleles.

The recently reported linkage disequilibrium between HLA-B14.1 and DR7 and B14.2 and DR1 has been confirmed in a study of 44 B14.1 and 40 B14.2 positive individuals. In addition, significant linkage disequilibrium was observed between BfF and B14.2. Data on 238 B14 positives (98 B14.1 and 140 B14.2), from a population of 4,238, continues to support the previous observation of associations between B14.1 and Aw32 and B14.2 and A3, A28 and Aw33. These findings add further evidence for the existence of B14 splits.