Department of Pharmacy, Union University College of Pharmacy, Jackson, TN, USA.
Department of Clinical Pharmacy and Translational Science, The University of Tennessee Health Science Center College of Pharmacy, Memphis, TN, USA.
J Pharm Pract. 2024 Dec;37(6):1405-1409. doi: 10.1177/08971900241256726. Epub 2024 May 23.
Peritoneal dialysis (PD) - associated peritonitis is a serious complication of peritoneal dialysis (PD). The 2022 International Society of Peritoneal Dialysis (ISPD) guidelines do not recommend intraperitoneal (IP) ampicillin for treatment of Enterococcal PD - associated peritonitis. To date, there is no in vivo data to support use of IP ampicillin for the treatment of . A 69-year-old man with a past medical history of end stage kidney disease (ESKD) requiring continuous cycling peritoneal dialysis (CCPD) was admitted to the hospital and treated for peritonitis with . The patient's CCPD prescription was 2.5% Dianeal with 5 total exchanges. IP ampicillin was added to the first 4 exchanges and additional ampicillin was added to the last fill. The patient successfully completed the treatment course with clinical cure. The use of IP ampicillin for . peritonitis is controversial and previously lacked compelling clinical evidence for or against its use. This case demonstrates treatment of peritonitis using a modified dosing strategy with ampicillin added to each CCPD exchange and last fill. The loss of ampicillin antimicrobial activity reported in vitro with was not supported by this case.
腹膜透析（PD）相关性腹膜炎是腹膜透析（PD）的严重并发症。2022 年国际腹膜透析学会（ISPD）指南不建议将腹腔内（IP）氨苄西林用于治疗肠球菌 PD 相关性腹膜炎。迄今为止，尚无体内数据支持 IP 氨苄西林用于治疗 。一名 69 岁男性，既往有终末期肾脏病（ESKD）病史，需要持续循环腹膜透析（CCPD），因腹膜炎住院并接受氨苄西林治疗。该患者的 CCPD 处方为含 2.5% Dianeal 的 5 总交换液。在最初的 4 次交换中加入 IP 氨苄西林，最后一次填充时再加入氨苄西林。患者成功完成了治疗疗程，临床治愈。腹腔内使用氨苄西林治疗 性腹膜炎存在争议，此前缺乏支持或反对其使用的有力临床证据。本病例证明了在每次 CCPD 交换和最后一次填充时加入氨苄西林的改良剂量策略治疗腹膜炎。本病例未支持体外研究中报道的 导致氨苄西林抗菌活性丧失的现象。
