Ke Junyi, Huang Shu, He Zhixiong, Lei Siyu, Lin Shiya, Duan Minchao
Guangxi Medical University, Nanning, China.
The Second Affiliated Hospital of Guangxi Medical University, Nanning, China.
Inflammation. 2025 Feb;48(1):15-24. doi: 10.1007/s10753-024-02045-y. Epub 2024 May 23.
TIGIT, a co-inhibitory receptor found on T cells and NK cells, transmits inhibitory signals upon binding to its ligand. This interaction suppresses the activation of various signaling pathways, leading to functional exhaustion of cells, ultimately dampening excessive inflammatory responses or facilitating immune evasion in tumors. Dysregulated TIGIT expression has been noted in T cells across different inflammatory conditions, exhibiting varying effects based on T cell subsets. TIGIT predominantly restrains the effector function of pro-inflammatory T cells, upholds the suppressive function of regulatory T cells, and influences Tfh maturation. Mechanistically, the IL27-induced transcription factors c-Maf and Blimp-1 are believed to be key regulators of TIGIT expression in T cells. Notably, TIGIT expression in T cells is implicated in lung diseases, particularly airway inflammatory conditions such as lung cancer, obstructive pulmonary disease, interstitial lung disease, sarcoidosis, and COVID-19. This review emphasizes the significance of TIGIT in the context of T cell immunity and airway inflammatory diseases.
TIGIT是一种在T细胞和自然杀伤细胞（NK细胞）上发现的共抑制受体，与配体结合后会传递抑制信号。这种相互作用会抑制各种信号通路的激活，导致细胞功能耗竭，最终抑制过度的炎症反应或促进肿瘤中的免疫逃逸。在不同炎症条件下的T细胞中，已发现TIGIT表达失调，根据T细胞亚群表现出不同的影响。TIGIT主要抑制促炎性T细胞的效应功能，维持调节性T细胞的抑制功能，并影响滤泡辅助性T细胞（Tfh）的成熟。从机制上讲，白细胞介素27（IL27）诱导的转录因子c-Maf和B淋巴细胞诱导成熟蛋白1（Blimp-1）被认为是T细胞中TIGIT表达的关键调节因子。值得注意的是，T细胞中的TIGIT表达与肺部疾病有关，特别是气道炎症性疾病，如肺癌、阻塞性肺疾病、间质性肺疾病、结节病和2019冠状病毒病（COVID-19）。这篇综述强调了TIGIT在T细胞免疫和气道炎症性疾病背景下的重要性。
