Dechesne C J, Sans A
Am J Otolaryngol. 1985 Sep-Oct;6(5):378-87. doi: 10.1016/s0196-0709(85)80016-8.
The development of human vestibular receptors was studied between the 7th and 14th gestational weeks using scanning electron microscopy. The development phase appeared to last longer than previously described. At 7 weeks, no receptors were individualized, the vestibular epithelium was plicated, and scarce nascent hair bundles could be seen grouped in a small area. At 8 weeks, all receptors were well differentiated. Modifications in crista shapes were evaluated qualitatively and quantitatively along the length of their profile. Their growth occurred in two quick steps with a pause between the 9th and 12th weeks, during which growth slowed and a transformation occurred. In the utricle, the epithelium decreased in thickness, and this process underwent a pause between the 8th and 11th weeks. These results demonstrate pauses in the maturation process of the vestibular receptors and show that the utricles develop one week in advance of the cristae. At 14 weeks, all receptors had an adult profile, but the cristae had only reached 55 per cent of their adult size. The ciliary apparatus appeared to be nearly mature in the utricle but was still growing in the cristae. The differentiation of ciliary tufts in the cristae displayed an apex-base gradient. These developmental patterns were compared with those described in the mouse.
利用扫描电子显微镜研究了妊娠第7至14周人类前庭感受器的发育情况。发育阶段似乎比先前描述的持续时间更长。在第7周时，感受器尚未分化，前庭上皮呈褶皱状，在小区域内可见稀疏的新生毛束聚集。在第8周时，所有感受器均已充分分化。沿着嵴的轮廓长度对嵴形状的变化进行了定性和定量评估。它们的生长分两个快速阶段进行，在第9至12周之间有一个停顿，在此期间生长放缓并发生了转变。在椭圆囊中，上皮厚度减小，该过程在第8至11周之间有一个停顿。这些结果表明前庭感受器成熟过程中有停顿，并且显示椭圆囊比嵴提前一周发育。在第14周时，所有感受器都具有成人的形态，但嵴仅达到其成人大小的55%。睫状器在椭圆囊中似乎已接近成熟，但在嵴中仍在生长。嵴中睫状束的分化呈现出从顶端到底部的梯度。将这些发育模式与小鼠中描述的模式进行了比较。
