Lavigne-Rebillard M, Pujol R
Anat Embryol (Berl). 1986;174(3):369-77. doi: 10.1007/BF00698787.
Thirteen human fetal cochleas were investigated by scanning electron microscopy. Our observations concentrated on the hair cell surface. Ciliogenesis appeared to start during the 11th week of gestation on the inner hair cells (IHCs) and one week later on the outer hair cells (OHCs). The earliest stages of stereociliary development were similar on both types of cell and were characterized by the presence of round bundles of cilia arising from the surrounding microvilli. A three-dimensional V-shaped arrangement suddenly appeared, accompanied by the disappearance of short cilia on the internal side. Between the 20th and the 22nd weeks of gestation, both types of hair cell had an adult stereociliary pattern, i.e. a rectilinear arrangement on IHCs and W-shaped on OHCs. However, there were signs of immaturity, such as a disarray of OHCs and the presence of the kinocilium, suggesting that the surface of the auditory hair cells achieves its maturation during the last trimester of pregnancy.
通过扫描电子显微镜对13个人类胎儿耳蜗进行了研究。我们的观察集中在毛细胞表面。纤毛发生似乎在妊娠第11周开始于内毛细胞（IHC），一周后在外毛细胞（OHC）开始。两种类型细胞的静纤毛发育最早阶段相似，其特征是从周围微绒毛产生圆形纤毛束。三维V形排列突然出现，同时内侧短纤毛消失。在妊娠第20至22周之间，两种类型的毛细胞都具有成人静纤毛模式，即内毛细胞上呈直线排列，外毛细胞上呈W形排列。然而，存在不成熟的迹象，例如外毛细胞排列紊乱和动纤毛的存在，这表明听觉毛细胞表面在妊娠晚期实现成熟。
