Ye-1，一种与HLA-B27淋巴母细胞系和一种致关节炎细菌发生交叉反应的单克隆抗体。
Ye-1, a monoclonal antibody that cross-reacts with HLA-B27 lymphoblastoid cell lines and an arthritis causing bacteria.
作者信息
Kono D H, Ogasawara M, Effros R B, Park M S, Waldord R L, Yu D T
出版信息
Clin Exp Immunol. 1985 Sep;61(3):503-8.
Abstract
A monoclonal antibody, Ye-1, was generated by immunizing BALB/c mice with Yersinia enterocolitica. This antibody also reacted with all of 12 B27 positive lymphoblastoid cell lines, but only four of 31 B27 negative ones. Three of the four reactive B27 negative cell lines were B7 positive. A B27 positive cell line which has lost the B27 expression because of experimentally-induced mutation became unreactive with the Ye-1. These findings support the possibility that there is cross-reactivity between HLA-B27 antigens and Y. enterocolitica.
摘要
通过用小肠结肠炎耶尔森菌免疫BALB/c小鼠产生了一种单克隆抗体Ye-1。该抗体也与所有12种B27阳性淋巴母细胞系发生反应，但在31种B27阴性细胞系中仅与4种发生反应。4种发生反应的B27阴性细胞系中有3种是B7阳性。一个因实验诱导突变而失去B27表达的B27阳性细胞系与Ye-1不再发生反应。这些发现支持了HLA-B27抗原与小肠结肠炎耶尔森菌之间存在交叉反应的可能性。
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