Department of Dentistry, School of Medicine, Nihon University, Tokyo, Japan.
Department of Dentistry, Yokohama Chuo Hospital, Kanagawa, Japan.
J Pak Med Assoc. 2024 May;74(5):984-986. doi: 10.47391/JPMA.9770.
Acute promyelocytic leukaemia (APL) is a form of acute myelogenous leukaemia. APL is characterised by anaemia due to suppression of normal haematopoiesis and infection. Haematopoietic stem cell transplantation (HSCT) is current option for the treatment of haematopoietic malignancies and is proving to be successful. Although HSCT has been effective for the treatment of haematopoietic malignant tumours, chronic graft-versushost disease (GVHD) but secondary cancers can occur, which is a serious complication and frequently involves the oral cavity and skin. Here, we report the case of tongue cancer occurring 17 years after transplantation in a patient who developed GVHD after haematopoietic stem cell transplantation and APL remission. To the best of our knowledge, this is the first report of secondary oral cancer after HSCT with APL as the primary disease.
急性早幼粒细胞白血病（APL）是一种急性髓系白血病。APL 的特征是由于正常造血受到抑制和感染导致贫血。造血干细胞移植（HSCT）是治疗血液恶性肿瘤的当前选择，并且正在被证明是成功的。尽管 HSCT 已被有效用于治疗血液恶性肿瘤，但慢性移植物抗宿主病（GVHD）和继发性癌症可能会发生，这是一种严重的并发症，经常涉及口腔和皮肤。在这里，我们报告了一例在移植后 17 年发生舌癌的病例，该患者在造血干细胞移植和 APL 缓解后发生 GVHD。据我们所知，这是首例以 APL 为首发疾病的 HSCT 后发生继发性口腔癌的报告。
