Applied Medical Sciences College, Laboratory Technology Department, Taibah University, Al-Madinah Al-Munwarah, Jeddah, north Obhur, Abdullah Althagfi.
Ethiop J Health Sci. 2023 Jul;33(4):711-720. doi: 10.4314/ejhs.v33i4.18.
This review aims to determine the potential role of Merkel Cell Polyomavirus (MCPyV) in the pathogenesis of cervical squamous cell carcinomas and adenocarcinomas.
A PRISMA systematic search appraisal was conducted. The Scopus, Web of Science, PubMed, EMBASE, Google Scholar, and MEDLINE databases for publications in English were searched up to September 2022 for all relevant articles. All articles that have outlined the contributions of the MCPyV to cervical squamous cell carcinomas and adenocarcinomas were included.
The six databases produced 6806 articles. Only six articles met the inclusion criteria and were included. The protocol of this review was submitted and registered with the PROSPERO (Code no. CRD42022369197). The total sample size across the articles was 1135; the age of the participants ranged between 18 and 75 years. In addition, the included articles were conducted between 2012 to 2016. All included articles have a cross-sectional design.Furthermore, different kinds of samples were collected in the reviewed articles, namely cervical tissue biopsies, cervical smears, formalin-fixed paraffin-embedded resection specimens, and cervical adenocarcinomas. Moreover, five articles showed no statistically significant association between the MCPyV and cervical squamous cell carcinomas and adenocarcinomas. In contrast, one article revealed a positive association between MCPyV and cervical squamous cell carcinomas and adenocarcinomas.
MCPyV could not be associated with the pathogenesis of cervical squamous cell carcinomas and adenocarcinomas. Further attention should be given to examining this association, and further studies with a large sample size are recommended to confirm these findings.
本综述旨在确定 Merkel 细胞多瘤病毒（MCPyV）在宫颈鳞状细胞癌和腺癌发病机制中的潜在作用。
采用 PRISMA 系统搜索评估。对 Scopus、Web of Science、PubMed、EMBASE、Google Scholar 和 MEDLINE 数据库中截至 2022 年 9 月的所有相关文章进行了英语出版物的检索，以查找所有概述 MCPyV 对宫颈鳞状细胞癌和腺癌的贡献的文章。
六个数据库共产生 6806 篇文章。只有 6 篇文章符合纳入标准并被纳入。本综述的方案已提交并在 PROSPERO（注册号：CRD42022369197）上注册。纳入的文章的总样本量为 1135 例；参与者的年龄在 18 至 75 岁之间。此外，纳入的文章发表于 2012 年至 2016 年期间。所有纳入的文章均采用横断面设计。此外，在综述文章中收集了不同类型的样本，包括宫颈组织活检、宫颈涂片、福尔马林固定石蜡包埋的切除标本和宫颈腺癌。此外，有 5 篇文章显示 MCPyV 与宫颈鳞状细胞癌和腺癌之间无统计学显著关联。相比之下，有 1 篇文章显示 MCPyV 与宫颈鳞状细胞癌和腺癌之间存在正相关。
MCPyV 不能与宫颈鳞状细胞癌和腺癌的发病机制相关。应进一步关注检验这种关联，建议开展具有更大样本量的进一步研究以证实这些发现。
