8例垂体功能减退患者诱导排卵以实现妊娠的结局
Outcomes of Ovulation Induction Aimed to Pregnancy in Eight Hypopituitarism Patients.
作者信息
Horibe Yu, Nakabayashi Akira, Murata Shuko, Hashimoto Tomomi, Tabata Tsutomu
机构信息
Gynecology, Tokyo Women's Medical University, Tokyo, JPN.
Obstetrics and Gynecology, Tokyo Women's Medical University, Tokyo, JPN.
出版信息
Cureus. 2024 Apr 23;16(4):e58819. doi: 10.7759/cureus.58819. eCollection 2024 Apr.
BACKGROUND
Female sex hormones work in concert. Gonadotropin-releasing hormone and ovulation-inducing agents are required in female patients with infertility owing to hormone dysregulation. Although drug-induced follicular development can be expected in patients with endogenous female hormone deficiency, data are lacking on the protocols and drugs used.
METHODS
We retrospectively examined the success rates of ovulation induction, assisted reproductive technology, and pregnancy outcomes in 66 cycles of eight patients with pituitary insufficiency at our hospital.
RESULTS
Ovulation occurred in 75.4% (49/66); 82.6% (38/46) of patients <40 years and 57.9% (11/19) of patients ≥40 years of age. Five of the eight patients became pregnant, and three delivered babies. The fertilization rate was 78% with in vitro fertilization, and the recombinant follicle-stimulating hormone usage was 3,717.1 ± 1,528.9 International Unit in hypopituitarism patients.
CONCLUSION
Hypopituitarism patients can achieve ovulation, pregnancy, and delivery after optimal gonadotropin administration. Further studies are needed to determine the effects of gonadotropins on other pituitary hormones, such as growth hormones.
背景
女性性激素协同发挥作用。对于因激素失调导致不孕的女性患者，促性腺激素释放激素和促排卵药物是必需的。尽管对于内源性女性激素缺乏的患者，药物诱导卵泡发育是可以预期的，但关于所使用的方案和药物的数据却很缺乏。
方法
我们回顾性研究了我院8例垂体功能不全患者66个周期的促排卵成功率、辅助生殖技术及妊娠结局。
结果
排卵率为75.4%（49/66）；年龄<40岁的患者排卵率为82.6%（38/46），年龄≥40岁的患者排卵率为57.9%（11/19）。8例患者中有5例怀孕，3例分娩。垂体功能减退患者体外受精的受精率为78%，重组促卵泡激素的使用量为3717.1±1528.9国际单位。
结论
垂体功能减退患者在给予最佳促性腺激素后可实现排卵、妊娠和分娩。需要进一步研究以确定促性腺激素对其他垂体激素（如生长激素）的影响。
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