Fafián-Labora Juan Antonio, Morente-López Miriam, Arufe María C
Grupo de Terapia Celular y Medicina Regenerativa, Departamento de Fisioterapia, Ciencias Biomédicas y Medicina, Universidade da Coruña, A Coruña 15006, Spain.
World J Stem Cells. 2019 Jun 26;11(6):337-346. doi: 10.4252/wjsc.v11.i6.337.
Organs whose source is the mesoderm lineage contain a subpopulation of stem cells that are able to differentiate among mesodermal derivatives (chondrocytes, osteocytes, adipocytes). This subpopulation of adult stem cells, called "mesenchymal stem cells" or "mesenchymal stromal cells (MSCs)", contributes directly to the homeostatic maintenance of their organs; hence, their senescence could be very deleterious for human bodily functions. MSCs are easily isolated and amenable their expansion because of the research demanding to test them in many diverse clinical indications. All of these works are shown by the rapidly expanding literature that includes many animal models. We do not have an in-depth understanding of mechanisms that induce cellular senescence, and to further clarify the consequences of the senescence process in MSCs, some hints may be derived from the study of cellular behaviour and , autophagy, mitochondrial stress and exosomal activity. In this particular work, we decided to review these biological features in the literature on MSC senescence over the last three years.
源自中胚层谱系的器官含有能够在中胚层衍生物（软骨细胞、骨细胞、脂肪细胞）之间分化的干细胞亚群。这种成年干细胞亚群，称为“间充质干细胞”或“间充质基质细胞（MSCs）”，直接有助于其器官的稳态维持；因此，它们的衰老可能对人体功能非常有害。由于在许多不同临床适应症中测试它们的研究需求，MSCs很容易分离且易于扩增。所有这些工作都体现在迅速扩展的文献中，其中包括许多动物模型。我们对诱导细胞衰老的机制没有深入的了解，为了进一步阐明MSCs衰老过程的后果，可以从对细胞行为、自噬、线粒体应激和外泌体活性的研究中获得一些线索。在这项具体工作中，我们决定回顾过去三年关于MSCs衰老的文献中的这些生物学特征。
