Department of Restorative Dentistry, Araraquara School of Dentistry, São Paulo State University (UNESP), Araraquara 14801-385, SP, Brazil.
Department of Physiology and Biochemistry, Wroclaw University of Health and Sport Sciences, 51-612 Wrocław, Poland.
Cells. 2024 May 20;13(10):880. doi: 10.3390/cells13100880.
MicroRNAs can interfere with protein function by suppressing their messenger RNA translation or the synthesis of its related factors. The function of brain-derived neurotrophic factor (BDNF) is essential to the proper formation and function of the nervous system and is seen to be regulated by many microRNAs. However, understanding how microRNAs influence BDNF actions within cells requires a wider comprehension of their integrative regulatory mechanisms. : In this literature review, we have synthesized the evidence of microRNA regulation on BDNF in cells and tissues, and provided an analytical discussion about direct and indirect mechanisms that appeared to be involved in BDNF regulation by microRNAs. : Searches were conducted on PubMed.gov using the terms "BDNF" AND "MicroRNA" and "brain-derived neurotrophic factor" AND "MicroRNA", updated on 1 September 2023. Papers without open access were requested from the authors. One hundred and seventy-one papers were included for review and discussion. Results and : The local regulation of BDNF by microRNAs involves a complex interaction between a series of microRNAs with target proteins that can either inhibit or enhance BDNF expression, at the core of cell metabolism. Therefore, understanding this homeostatic balance provides resources for the future development of vector-delivery-based therapies for the neuroprotective effects of BDNF.
微小 RNA 可以通过抑制其信使 RNA 翻译或相关因子的合成来干扰蛋白质功能。脑源性神经营养因子 (BDNF) 的功能对神经系统的正常形成和功能至关重要，并且被认为受到许多微小 RNA 的调节。然而，要了解微小 RNA 如何在细胞内影响 BDNF 的作用，需要更广泛地理解它们的综合调节机制。在这篇文献综述中，我们综合了微小 RNA 对细胞和组织中 BDNF 的调节作用的证据，并对直接和间接机制进行了分析讨论，这些机制似乎参与了微小 RNA 对 BDNF 的调节。在 PubMed.gov 上使用术语“BDNF”和“微小 RNA”以及“脑源性神经营养因子”和“微小 RNA”进行了搜索，并于 2023 年 9 月 1 日进行了更新。向作者请求了没有开放获取的论文。共纳入 171 篇论文进行综述和讨论。结果和讨论微小 RNA 对 BDNF 的局部调节涉及一系列微小 RNA 与靶蛋白之间的复杂相互作用，这些微小 RNA 可以抑制或增强 BDNF 的表达，这是细胞代谢的核心。因此，了解这种体内平衡为未来基于载体传递的 BDNF 神经保护作用的治疗方法的发展提供了资源。
