Rubino Raffaella, Trizzino Marcello, Pipitò Luca, Sucato Giuseppe, Santoro Marco, Maugeri Rosario, Iacopino Domenico Gerardo, Giammanco Giovanni Maurizio, Siragusa Sergio, Cascio Antonio
Infectious and Tropical Diseases Unit, Sicilian Regional Reference Center for the Fight against AIDS, AOU Policlinico "P. Giaccone", 90127 Palermo, Italy.
Antimicrobial Stewardship Team, AOU Policlinico "P. Giaccone", 90127 Palermo, Italy.
Antibiotics (Basel). 2024 May 10;13(5):432. doi: 10.3390/antibiotics13050432.
Ventriculitis and nosocomial meningitis caused by carbapenem-resistant Gram-negative and vancomycin-resistant Gram-positive bacteria represent a growing treatment challenge. A case of ventriculitis and bacteremia caused by carbapenem-resistant, KPC-producing and vancomycin-resistant in a young woman with acute leukemia who was successfully treated with meropenem/vaborbactam (MVB), rifampicin, and linezolid is described in this paper. This case report emphasizes the importance of a multidisciplinary strategy, including infectious focus control, for the treatment of device-associated central nervous system (CNS) infections from multidrug-resistant bacteria. Considering the novel resistance patterns, more research on drug penetration into the central nervous system, as well as on the necessity of association therapies, is needed.
由耐碳青霉烯革兰氏阴性菌和耐万古霉素革兰氏阳性菌引起的脑室炎和医院获得性脑膜炎对治疗构成了越来越大的挑战。本文描述了一名患有急性白血病的年轻女性发生耐碳青霉烯、产KPC且耐万古霉素的脑室炎和菌血症的病例，该患者通过美罗培南/巴硼巴坦（MVB）、利福平及利奈唑胺成功治愈。本病例报告强调了多学科策略（包括控制感染源）对于治疗由多重耐药菌引起的与器械相关的中枢神经系统（CNS）感染的重要性。鉴于新出现的耐药模式，需要对药物在中枢神经系统中的渗透情况以及联合治疗的必要性开展更多研究。
