Zhang Ming, Zhu Chongyu
College of Chemistry and Chemical Engineering, Donghua University, Shanghai 201620, China.
Gels. 2024 May 14;10(5):331. doi: 10.3390/gels10050331.
Human defense against infection remains a global topic. In addition to developing novel anti-infection drugs, therapeutic drug delivery strategies are also crucial to achieving a higher efficacy and lower toxicity of these drugs for treatment. The application of hydrogels has been proven to be an effective localized drug delivery approach to treating infections without generating significant systemic adverse effects. The recent emerging dynamic hydrogels further show power as injectable formulations, giving new tools for clinical treatments. In this review, we delve into the potential applications of dynamic hydrogels in antibacterial and antiviral treatments and elaborate on their molecular designs and practical implementations. By outlining the chemical designs underlying these hydrogels, we discuss how the choice of dynamic chemical bonds affects their stimulus responsiveness, self-healing capabilities, and mechanical properties. Afterwards, we focus on how to endow dynamic hydrogels with anti-infection properties. By comparing different drug-loading methods, we highlight the advantages of dynamic chemical bonds in achieving sustained and controlled drug release. Moreover, we also include the design principles and uses of hydrogels that possess inherent anti-infective properties. Furthermore, we explore the design principles and applications of hydrogels with inherent anti-infective properties. Finally, we briefly summarize the current challenges faced by dynamic hydrogels and present a forward-looking vision for their future development. Through this review, we expect to draw more attention to these therapeutic strategies among scientists working with chemistry, materials, as well as pharmaceutics.
人类抵御感染仍然是一个全球性话题。除了开发新型抗感染药物外，治疗性药物递送策略对于实现这些药物更高的疗效和更低的毒性以用于治疗也至关重要。水凝胶的应用已被证明是一种有效的局部药物递送方法，可用于治疗感染而不会产生明显的全身不良反应。最近出现的动态水凝胶进一步展现出作为可注射制剂的优势，为临床治疗提供了新工具。在本综述中，我们深入探讨动态水凝胶在抗菌和抗病毒治疗中的潜在应用，并详细阐述其分子设计和实际应用。通过概述这些水凝胶的化学设计，我们讨论了动态化学键的选择如何影响它们的刺激响应性、自愈能力和机械性能。之后，我们专注于如何赋予动态水凝胶抗感染特性。通过比较不同的载药方法，我们突出了动态化学键在实现药物持续和可控释放方面的优势。此外，我们还介绍了具有固有抗感染特性的水凝胶的设计原理和用途。最后，我们简要总结了动态水凝胶目前面临的挑战，并对其未来发展提出前瞻性展望。通过本综述，我们期望在化学、材料以及制药领域的科学家中引起对这些治疗策略更多的关注。
