Andercou Octavian, Andrei Maria Cristina, Gheban Dan, Marian Dorin, Coman Horațiu F, Oprea Valentin Aron, Mihaileanu Florin Vasile, Ciocan Razvan, Cucuruz Beatrix, Stancu Bogdan
Department of Surgery, Emergency County Hospital Cluj, University of Medicine and Pharmacy Iuliu Hatieganu, 400347 Cluj Napoca, Romania.
Vascular Surgery Department, Satu Mare County Emergency Hospital, 440192 Satu Mare, Romania.
Diagnostics (Basel). 2024 May 8;14(10):989. doi: 10.3390/diagnostics14100989.
This prospective study aims to illustrate the histopathological arterial changes in the popliteal artery in peripheral arterial disease of the lower limbs.
A total of 60 popliteal artery segments taken from patients who had undergone lower limb amputation were examined between April and June 2023. The degree of arterial stenosis, medial calcinosis, and the vasa vasorum changes in the arterial adventitia were quantified. The presence of risk factors for atherosclerosis was also observed.
Atherosclerotic plaque was found in all of the examined segments. Medial calcinosis was observed in 40 (66.6%) of the arterial segments. A positive association between the degree of arterial stenosis and the vasa vasorum changes in the arterial adventitia was also found ( = 0.025). The level of blood sugar and cholesterol were predictive factors for the severity of atherosclerosis.
Atherosclerosis and medial calcinosis are significant in patients who underwent lower limb amputation. Medial calcinosis causes damage to the arterial wall and leads to a reduction in responsiveness to dilator stimuli.
本前瞻性研究旨在阐明下肢外周动脉疾病患者腘动脉的组织病理学动脉变化。
2023年4月至6月期间，对60例接受下肢截肢患者的腘动脉节段进行了检查。对动脉狭窄程度、中层钙化以及动脉外膜的血管滋养管变化进行了量化。还观察了动脉粥样硬化危险因素的存在情况。
在所有检查节段均发现动脉粥样硬化斑块。40个（66.6%）动脉节段观察到中层钙化。还发现动脉狭窄程度与动脉外膜血管滋养管变化之间存在正相关（=0.025）。血糖和胆固醇水平是动脉粥样硬化严重程度的预测因素。
动脉粥样硬化和中层钙化在接受下肢截肢的患者中较为显著。中层钙化会损害动脉壁并导致对扩张刺激的反应性降低。
