Tsai Yao-Kuang, Lin Li-Fan, Cheng Cheng-Yi, Wong Ching-Yee Oliver, Wang Wei-Hsung, Shen Daniel Hueng-Yuan, Su Sui-Lung, Chen En-Shih, Chen Tzai-Yang, Chen I-Feng
Department of Nuclear Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114202, Taiwan.
Department of Nuclear Medicine, Taichung Armed Forces General Hospital, Taichung 411228, Taiwan.
Diagnostics (Basel). 2024 May 14;14(10):1010. doi: 10.3390/diagnostics14101010.
The biokinetics of radioiodine (RAI) in thyroid cancer patients are complex. This study aims to develop a practical approach for assessing RAI biokinetics to predict patient discharge time and estimate radiation exposure to caregivers.
We retrospectively reviewed data from patients with differentiated thyroid carcinoma undergoing RAI treatment. Serial radiation dose rates were dynamically collected during hospitalization and fitted to a biexponential model to assess the biokinetic features: RAI uptake fraction of thyroid tissue () and effective half-life of extra-thyroid tissue (). Correlations with Tc thyroid uptake ratio (TcUR), radiation retention ratio (RR), renal function, and body mass index (BMI) were analyzed.
Thirty-five patients were enrolled. The derived was 0.08 ± 0.06 and was 7.57 ± 1.45 h. Pearson's correlation analysis revealed a significant association between and both TcUR and RR ( < 0.05), while correlated with renal function and BMI ( < 0.05).
This novel and practical method assessing RAI biokinetics demonstrates consistency with other parameters and related studies, enhancing the model reliability. It shows promise in predicting an appropriate discharge time and estimating radiation exposure to caregivers, allowing for modifications to radiation protection precautions to follow ALARA principle and minimize the potential risks from radiation exposure.
甲状腺癌患者体内放射性碘（RAI）的生物动力学较为复杂。本研究旨在开发一种评估RAI生物动力学的实用方法，以预测患者出院时间并估算护理人员的辐射暴露剂量。
我们回顾性分析了接受RAI治疗的分化型甲状腺癌患者的数据。在住院期间动态收集系列辐射剂量率，并将其拟合到双指数模型中，以评估生物动力学特征：甲状腺组织的RAI摄取分数（）和甲状腺外组织的有效半衰期（）。分析了其与锝甲状腺摄取率（TcUR）、辐射滞留率（RR）、肾功能和体重指数（BMI）的相关性。
共纳入35例患者。得出的为0.08±0.06，为7.57±1.45小时。Pearson相关性分析显示与TcUR和RR均存在显著关联（<0.05），而与肾功能和BMI相关（<0.05）。
这种评估RAI生物动力学的新颖实用方法与其他参数及相关研究具有一致性，提高了模型的可靠性。它在预测合适的出院时间和估算护理人员的辐射暴露剂量方面显示出前景，能够根据“尽可能合理地降低辐射剂量”（ALARA）原则调整辐射防护措施，并将辐射暴露的潜在风险降至最低。
