College of Life Sciences, Laboratory for Marine Biology and Biotechnology of Pilot National Laboratory for Marine Science and Technology (Qingdao), Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhejiang University, Hangzhou 310058, China.
Government Post Graduate College Miran Shah, Miran Shah 28200, Pakistan.
Mar Drugs. 2024 May 15;22(5):221. doi: 10.3390/md22050221.
Virus infection causes the metabolic disorder of host cells, whereas the metabolic disorder of cells is one of the major causes of tumorigenesis, suggesting that antiviral molecules might possess anti-tumor activities by regulating cell metabolism. As the key regulators of gene expression, long non-coding RNAs (lncRNAs) play vital roles in the regulation of cell metabolism. However, the influence of antiviral lncRNAs on tumorigenesis has not been explored. To address this issue, the antiviral and anti-tumor capacities of shrimp lncRNAs were characterized in this study. The results revealed that shrimp lncRNA06, having antiviral activity in shrimp, could suppress the tumorigenesis of human gastric cancer stem cells (GCSCs) via triggering apoptosis of GCSCs in a cross-species manner. Shrimp lncRNA06 could sponge human miR-17-5p to suppress the stemness of GCSCs via the miR-17-5p-p21 axis. At the same time, shrimp lncRNA06 could bind to ATP synthase subunit beta (ATP5F1B) to enhance the stability of the ATP5F1B protein in GCSCs, thus suppressing the tumorigenesis of GCSCs. The in vivo data demonstrated that shrimp lncRNA06 promoted apoptosis and inhibited the stemness of GCSCs through interactions with ATP5F1B and miR-17-5p, leading to the suppression of the tumorigenesis of GCSCs. Therefore, our findings highlighted that antiviral lncRNAs possessed anti-tumor capacities and that antiviral lncRNAs could be the anti-tumor reservoir for the treatment of human cancers.
病毒感染会导致宿主细胞的代谢紊乱，而细胞代谢紊乱是肿瘤发生的主要原因之一，这表明抗病毒分子可能通过调节细胞代谢发挥抗肿瘤活性。长链非编码 RNA（lncRNA）作为基因表达的关键调节剂，在细胞代谢的调控中发挥着重要作用。然而，抗病毒 lncRNA 对肿瘤发生的影响尚未被探索。为了解决这个问题，本研究对虾 lncRNA06 的抗病毒和抗肿瘤能力进行了表征。结果表明，具有抗病毒活性的虾 lncRNA06 可以通过跨物种触发 GCSC 凋亡来抑制人胃癌干细胞（GCSC）的肿瘤发生。虾 lncRNA06 可以通过海绵吸附人 miR-17-5p 来抑制 GCSC 的干性，通过 miR-17-5p-p21 轴。同时，虾 lncRNA06 可以与 ATP 合酶亚基β（ATP5F1B）结合，增强 GCSC 中 ATP5F1B 蛋白的稳定性，从而抑制 GCSC 的肿瘤发生。体内数据表明，虾 lncRNA06 通过与 ATP5F1B 和 miR-17-5p 的相互作用促进 GCSC 的凋亡和抑制其干性，从而抑制 GCSC 的肿瘤发生。因此，我们的研究结果表明，抗病毒 lncRNA 具有抗肿瘤能力，抗病毒 lncRNA 可能是治疗人类癌症的抗肿瘤储备库。
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