Department of Gastrointestinal Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China.
Oncol Rep. 2021 Dec;46(6). doi: 10.3892/or.2021.8207. Epub 2021 Oct 22.
Long non‑coding RNAs (lncRNAs) fulfill important roles in the majority of cellular processes. Previous studies have demonstrated that lncRNAs are involved in the pathogenesis of various diseases, including cancer. However, to date, the functions of only a small number of the known lncRNAs have been well‑documented. lncRNAs comprise a class of multifunctional non‑coding transcripts that are able to interact with different types of biomolecules. Interactions between lncRNAs and RNA‑binding proteins (RBPs) provide an important mechanism through which lncRNAs exert their regulatory functions, mainly through findings on 'generalized RBPs'. Regulatory effects on lncRNAs mediated by RBPs have also been explored. Taking account of the research that has been completed to date, the continued and in‑depth study of the bidirectional interactions between lncRNAs and RBPs will prove to be of major importance for understanding the pathogenesis of cancer and for developing effective therapies. The present review aims to explore the interactions between lncRNAs and RBPs that have been investigated in cancer, taking into consideration several different aspects, including the regulation of expression, subcellular localization and the mediation of diverse functions.
长链非编码 RNA（lncRNA）在大多数细胞过程中发挥着重要作用。先前的研究表明，lncRNA 参与了多种疾病的发病机制，包括癌症。然而，迄今为止，只有少数已知的 lncRNA 的功能得到了很好的记录。lncRNA 是一类多功能的非编码转录本，能够与不同类型的生物分子相互作用。lncRNA 与 RNA 结合蛋白（RBP）之间的相互作用提供了一个重要的机制，通过该机制，lncRNA 发挥其调节功能，主要是通过“通用 RBP”的发现。RBP 介导的对 lncRNA 的调节作用也已经被探索。考虑到迄今为止已经完成的研究，lncRNA 和 RBP 之间的双向相互作用的持续和深入研究将被证明对于理解癌症的发病机制和开发有效的治疗方法非常重要。本综述旨在探讨在癌症中研究的 lncRNA 和 RBP 之间的相互作用，考虑了几个不同的方面，包括表达的调节、亚细胞定位和多种功能的介导。
