Akbar A N, Giardina P J, Hilgartner M W, Grady R W
Clin Exp Immunol. 1985 Nov;62(2):397-404.
Multiply transfused patients with beta-thalassaemia major have elevated serum immunoglobulin levels and a transfusion-related increase in (T8+) T-suppressor cells. We report here that these patients also have a significantly increased (P less than 0.001) proportion of B-cells that contain cytoplasmic immunoglobulin when visualized immediately upon isolation. On the other hand, the same cell populations do not exhibit an increase in the proportion of immunoglobulin-secreting cells as measured by a reverse haemolytic plaque assay. These results, together with those of ongoing studies, suggest that the cells containing the cytoplasmic immunoglobulin are likely to be terminally differentiated B-cells which persist in the circulation. While the reason for this phenomenon is not yet known, we have found that the increase in these cells is transfusion-related.
多次输血的重型β地中海贫血患者血清免疫球蛋白水平升高，且与输血相关的（T8 +）T抑制细胞增多。我们在此报告，这些患者在分离后立即观察时，含有细胞质免疫球蛋白的B细胞比例也显著增加（P小于0.001）。另一方面，通过反向溶血空斑试验测定，相同细胞群体中分泌免疫球蛋白的细胞比例并未增加。这些结果以及正在进行的研究结果表明，含有细胞质免疫球蛋白的细胞可能是终末分化的B细胞，它们持续存在于循环中。虽然这种现象的原因尚不清楚，但我们发现这些细胞的增加与输血有关。
