Department of Paediatrics, College of Medicine, University of Nigeria Ituku/Ozalla and University of Nigeria Teaching Hospital Ituku/Ozalla, Enugu, Enugu State, Nigeria. Email:
Department of Community Medicine, Ebonyi State University, Abakiliki, Ebonyi state, Nigeria.
West Afr J Med. 2024 Mar 29;41(3):251-257.
Children with ostium secundum atrial septal defect (OS ASD) usually present with varying degrees of ventricular dysfunction.
This study aimed to evaluate the left ventricular systolic function of children with OS ASD compared with control.
This was a cross-sectional study involving 113 children with OS ASD and 113 age- and sex- matched controls. Their age ranged from 1 month to 16 years. There were 49 males and 64 females in each group. Left ventricular systolic function of children with isolated OS ASD were compared with that of controls using echocardiography. Subjects and controls who fulfilled the inclusion criteria were consecutively recruited in the study. The data elicited from the study were analyzed with the IBM SPSS version 20 (IBM Corp, Chicago).
The mean left ventricular mass (LV mass) of the control, 93.9±113.6 gm was significantly higher than that of subjects with OS ASD, 39.4±74.3 gm, (Mann Whitney U= 4.266, p< 0.001). Similarly, the mean left ventricular internal diameter in diastole (LVIDd) of the control,25.8±11.7 mm was significantly higher than that of participants with OS ASD, 19.9±7.1 mm (Mann Whitney U=4.522, p<0.001). The mean interventricular septal diameter in systole (IVSs) of the control, 7.2±3.5 mm was higher than that of participants with OS ASD, 5.0±1.9 mm and the mean difference was found to be statistically significant, (Student t=5.738, p<0.001). The mean left ventricular internal diameter in systole (LVIDs) of the control, 16.2±7.6 mm was significantly higher than that of participants with OS ASD, 12.9±5.8 mm, (Student t= 3.660, p< 0.001). There was no significant correlation between the size of interatrial septal defect of children with OS ASD and left ventricular systolic function and age :(Corr. Coef. 0.065, p= 0.492) ; EF( Corr. Coef. 0.121,p=0.202), FS (Corr. Coef. 0.139, p=0.143).
Children with OS ASD had lower left ventricular mass compared with those with control. Females seem to have higher function than males.
卵圆孔未闭（OS ASD）患儿通常表现为不同程度的心室功能障碍。
本研究旨在评估 OS ASD 患儿的左心室收缩功能与对照组相比。
这是一项横断面研究，共纳入 113 例 OS ASD 患儿和 113 例年龄和性别匹配的对照组。年龄范围为 1 个月至 16 岁。每组各有 49 名男性和 64 名女性。使用超声心动图比较单纯 OS ASD 患儿与对照组的左心室收缩功能。符合纳入标准的受试者和对照组被连续纳入研究。使用 IBM SPSS 版本 20（IBM 公司，芝加哥）对研究中获得的数据进行分析。
对照组的左心室质量（LV mass）平均值为 113.6±113.6gm，明显高于 OS ASD 组的 39.4±74.3gm（Mann Whitney U=4.266，p<0.001）。同样，对照组的舒张期左心室内径（LVIDd）平均值为 25.8±11.7mm，明显高于 OS ASD 组的 19.9±7.1mm（Mann Whitney U=4.522，p<0.001）。对照组的收缩期室间隔厚度（IVSs）平均值为 7.2±3.5mm，高于 OS ASD 组的 5.0±1.9mm，差异有统计学意义（Student t=5.738，p<0.001）。对照组的收缩期左心室内径（LVIDs）平均值为 16.2±7.6mm，明显高于 OS ASD 组的 12.9±5.8mm（Student t=3.660，p<0.001）。OS ASD 患儿房间隔缺损的大小与左心室收缩功能和年龄之间无明显相关性：（相关系数 0.065，p=0.492）；EF（相关系数 0.121，p=0.202），FS（相关系数 0.139，p=0.143）。
与对照组相比，OS ASD 患儿的左心室质量较低。女性的功能似乎高于男性。
