In contemporary society, social media pervades every aspect of daily life, offering significant benefits such as enhanced access to information, improved interconnectivity, and fostering community among its users. However, its usage, particularly when excessive, can lead to negative psychological outcomes, including the prevalence of social media addiction (SMA) among adolescents. While extensive research has been conducted on the phenomenon of SMA, there is a notable paucity of studies examining the link between individual levels of self-compassion and susceptibility to SMA. This study aims to investigate the correlation between self-compassion and SMA in college students, while also examining the potential mediating influence of gratitude. The study sampled 1131 college students who engaged in an anonymous online survey. This survey utilized the Chinese translations of the Self-Compassion Scale, Gratitude Questionnaire, and SMA Scale. For data analysis, validated factor analysis was performed using IBM® SPSS® AMOS™ version 23. Correlation analyses were carried out with IBM® SPSS® version 22.0, and the PROCESS macro (Model 4) was employed to assess path and mediation effects. Higher levels of positive self-compassion were found to mitigate the effects of SMA, while elevated levels of negative self-compassion were associated with an increase in such addiction. The study further revealed that gratitude played a partial mediating role in the relationship between self-compassion and SMA. Specifically, positive self-compassion can reduce symptoms of SMA by enhancing levels of gratitude, whereas negative self-compassion may worsen these symptoms by diminishing gratitude. Positive self-compassion is instrumental in fostering personal growth among college students, with gratitude serving as a significant mediator in reducing SMA.