School of Biology & Basic Medical Sciences, Medical College of Soochow University, Suzhou 215123, China.
The Second Clinical Medical School, Shaanxi University of Chinese Medicine, Xianyang 712046, China.
Asian J Psychiatr. 2024 Jul;97:104080. doi: 10.1016/j.ajp.2024.104080. Epub 2024 May 18.
This study investigates specific changes in brain function during cognitive and emotional tasks in patients with schizophrenia and a history of violence (VSCZ) compared with non-violent patients with schizophrenia and healthy controls. A comprehensive literature search was conducted at the Web of Science, Medline, and PubMed. Ten studies met the inclusion criteria. In which, eight studies compared brain activation between patients with VSCZ and non-violent patients with schizophrenia, and the former exhibited increased activation at the middle occipital gyrus and rectus compared with the latter. Seven studies compared brain activation between patients with VSCZ and controls, and the former exhibited increased activation at the anterior cingulate cortex, cerebellum VI region, lingual gyrus and fusiform. Subgroup analysis in five studies performing emotional tasks revealed that patients with VSCZ showed increased activation at the middle occipital gyrus compared with non-violent patients with schizophrenia. Our findings suggest that abnormal emotion perception and regulation significantly contribute to the increased risk of violence in patients with schizophrenia. Notably, the middle occipital gyrus and rectus emerge as key neurophysiological correlates associated with this phenomenon.
本研究调查了伴有暴力史的精神分裂症患者（VSCZ）与无暴力精神分裂症患者和健康对照组在认知和情绪任务中大脑功能的特定变化。在 Web of Science、Medline 和 PubMed 上进行了全面的文献检索。符合纳入标准的有十项研究。其中，八项研究比较了 VSCZ 患者与无暴力精神分裂症患者之间的大脑激活情况，前者在中枕叶和直回的激活程度高于后者。七项研究比较了 VSCZ 患者与对照组之间的大脑激活情况，前者在前扣带回皮质、小脑 VI 区、舌回和梭状回的激活程度更高。五项进行情绪任务的研究进行了亚组分析，结果表明 VSCZ 患者的中枕叶激活程度高于无暴力精神分裂症患者。我们的研究结果表明，异常的情绪感知和调节显著增加了精神分裂症患者发生暴力的风险。值得注意的是，中枕叶和直回成为与这种现象相关的关键神经生理学关联。
