• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

长非编码 RNA LINC00930 靶向 miR-6792-3p/ZBTB16 调控胰腺癌的增殖和 EMT。

Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16 regulates the proliferation and EMT of pancreatic cancer.

机构信息

Research Center of Clinical Medical, Department of General Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, 226001, P. R. China.

The Sixth People's Hospital of Nantong, Nantong, 226001, P. R. China.

出版信息

BMC Cancer. 2024 May 24;24(1):638. doi: 10.1186/s12885-024-12365-9.

DOI:10.1186/s12885-024-12365-9
PMID:38789960
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11127394/
Abstract

Emerging evidence suggests the dysregulation of long non-coding RNAs (lncRNAs) involved in pancreatic cancer (PC). However, the function of LINC00930 in PC has not been elaborated. In this study, we found that LINC00930 was significantly down-regulated in PC cell lines and tissues, and associated with tumor size, lymphatic metastasis, TNM stage and poor prognosis. According to the bioinformatics database, the downregulation of LINC00930 was a common event in PC associated with prognosis and EMT. Overexpression of LINC00930 inhibited the aggressive cancer phenotypes including proliferation, metastasis and epithelial-mesenchymal transition (EMT) of PC in vitro and in vivo. Bioinformatics and dual-luciferase reporter assay indicated that miR-6792-3p could directly bind to LINC00930. Additionally, the Zinc finger and BTB domain containing 16 (ZBTB16) was significantly declined in PC, which was predicted to be the downstream gene of miR-6792-3p. MiR-6792-3p mimic rescued the decreased proliferation, metastasis and EMT caused by ZBTB16 in PC cells. The LINC00930/miR-6792-3p/ZBTB16 axis was associated with the malignant progression and process of PC. The relative expression of LINC00930 was negatively correlated with the expression of miR-6792-3p and was closely linked with ZBTB16 levels in PC. LINC00930 might serve as a potential prognostic biomarker and therapeutic target for PC.

摘要

越来越多的证据表明，长链非编码 RNA（lncRNA）在胰腺癌（PC）中的失调。然而，LINC00930 在 PC 中的功能尚未阐述。在本研究中，我们发现 LINC00930 在 PC 细胞系和组织中显著下调，并与肿瘤大小、淋巴转移、TNM 分期和预后不良相关。根据生物信息学数据库，LINC00930 的下调是 PC 中与预后和 EMT 相关的常见事件。LINC00930 的过表达抑制了 PC 体外和体内侵袭性癌症表型，包括增殖、转移和上皮-间充质转化（EMT）。生物信息学和双荧光素酶报告基因实验表明，miR-6792-3p 可以直接结合 LINC00930。此外，锌指和 BTB 结构域包含 16 （ZBTB16）在 PC 中显著下降，预测是 miR-6792-3p 的下游基因。miR-6792-3p 模拟物挽救了 ZBTB16 引起的 PC 细胞增殖、转移和 EMT 的减少。LINC00930/miR-6792-3p/ZBTB16 轴与 PC 的恶性进展和过程有关。LINC00930 的相对表达与 miR-6792-3p 的表达呈负相关，并且与 PC 中 ZBTB16 水平密切相关。LINC00930 可能作为 PC 的潜在预后生物标志物和治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/81161d5de183/12885_2024_12365_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/ef4cd753458c/12885_2024_12365_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/89112d09fc4e/12885_2024_12365_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/ceca165d7ec2/12885_2024_12365_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/4e0f24c4915c/12885_2024_12365_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/b0b74715079f/12885_2024_12365_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/2d1efd016549/12885_2024_12365_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/81161d5de183/12885_2024_12365_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/ef4cd753458c/12885_2024_12365_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/89112d09fc4e/12885_2024_12365_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/ceca165d7ec2/12885_2024_12365_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/4e0f24c4915c/12885_2024_12365_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/b0b74715079f/12885_2024_12365_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/2d1efd016549/12885_2024_12365_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c824/11127394/81161d5de183/12885_2024_12365_Fig7_HTML.jpg

相似文献

1
Long non-coding RNA LINC00930 targeting miR-6792-3p/ZBTB16 regulates the proliferation and EMT of pancreatic cancer.长非编码 RNA LINC00930 靶向 miR-6792-3p/ZBTB16 调控胰腺癌的增殖和 EMT。
BMC Cancer. 2024 May 24;24(1):638. doi: 10.1186/s12885-024-12365-9.
2
LncRNA ADPGK-AS1 promotes pancreatic cancer progression through activating ZEB1-mediated epithelial-mesenchymal transition.长链非编码 RNA ADPGK-AS1 通过激活 ZEB1 介导的上皮-间充质转化促进胰腺癌进展。
Cancer Biol Ther. 2018 Jul 3;19(7):573-583. doi: 10.1080/15384047.2018.1423912. Epub 2018 Apr 19.
3
Silencing of long noncoding RNA LINC00958 prevents tumor initiation of pancreatic cancer by acting as a sponge of microRNA-330-5p to down-regulate PAX8.长链非编码 RNA LINC00958 通过作为 microRNA-330-5p 的海绵来下调 PAX8 从而防止胰腺癌的肿瘤发生。
Cancer Lett. 2019 Apr 1;446:49-61. doi: 10.1016/j.canlet.2018.12.017. Epub 2019 Jan 9.
4
Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition.环状STK39的下调通过海绵化mir-140-3p和调节TRAM2介导的上皮-间质转化来抑制胰腺癌进展。
Apoptosis. 2023 Aug;28(7-8):1024-1034. doi: 10.1007/s10495-023-01813-9. Epub 2023 Apr 11.
5
MiR-203a-3p Inhibits Pancreatic Cancer Cell Proliferation, EMT, and Apoptosis by Regulating SLUG.miR-203a-3p 通过调控 SLUG 抑制胰腺癌细胞增殖、上皮间质转化和凋亡。
Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033819898729. doi: 10.1177/1533033819898729.
6
HOXA-AS2 Promotes Proliferation and Induces Epithelial-Mesenchymal Transition via the miR-520c-3p/GPC3 Axis in Hepatocellular Carcinoma.HOXA-AS2通过miR-520c-3p/GPC3轴促进肝癌细胞增殖并诱导上皮-间质转化
Cell Physiol Biochem. 2018;50(6):2124-2138. doi: 10.1159/000495056. Epub 2018 Nov 9.
7
MicroRNA-148a-3p suppresses epithelial-to-mesenchymal transition and stemness properties via Wnt1-mediated Wnt/β-catenin pathway in pancreatic cancer.微小 RNA-148a-3p 通过 Wnt1 介导的 Wnt/β-连环蛋白通路抑制胰腺癌中的上皮间质转化和干性。
J Cell Mol Med. 2020 Nov;24(22):13020-13035. doi: 10.1111/jcmm.15900. Epub 2020 Oct 7.
8
Long non-coding RNA VPS9D1-AS1 enhances proliferation, invasion, and epithelial-mesenchymal transition in endometrial cancer via miR-377-3p/SGK1.长链非编码 RNA VPS9D1-AS1 通过 miR-377-3p/SGK1 促进子宫内膜癌细胞的增殖、侵袭和上皮间质转化。
Kaohsiung J Med Sci. 2022 Nov;38(11):1048-1059. doi: 10.1002/kjm2.12606. Epub 2022 Oct 17.
9
Long non-coding RNA FAM83A antisense RNA 1 (lncRNA FAM83A-AS1) targets microRNA-141-3p to regulate lung adenocarcinoma cell proliferation, migration, invasion, and epithelial-mesenchymal transition progression.长链非编码 RNA FAM83A 反义 RNA 1（lncRNA FAM83A-AS1）靶向 microRNA-141-3p 调控肺腺癌细胞增殖、迁移、侵袭和上皮间质转化进展。
Bioengineered. 2022 Mar;13(3):4964-4977. doi: 10.1080/21655979.2022.2037871.
10
MiR-652 inhibits acidic microenvironment-induced epithelial-mesenchymal transition of pancreatic cancer cells by targeting ZEB1.微小RNA-652通过靶向锌指E盒结合蛋白1抑制酸性微环境诱导的胰腺癌细胞上皮-间质转化。
Oncotarget. 2015 Nov 24;6(37):39661-75. doi: 10.18632/oncotarget.5350.

引用本文的文献

1
Bioinformatics analysis identifies ZBTB16 as a potential immune biomarker for lung cancer and pan-cancer.生物信息学分析确定ZBTB16为肺癌和泛癌的潜在免疫生物标志物。
Front Genet. 2025 Jun 9;16:1541732. doi: 10.3389/fgene.2025.1541732. eCollection 2025.
2
tRF-1:28-Val-CAC-2 promotes the development of nasopharyngeal cancer by targeting EPHB2.tRF-1:28-Val-CAC-2 通过靶向EPHB2促进鼻咽癌的发展。
Front Oncol. 2025 May 23;15:1564601. doi: 10.3389/fonc.2025.1564601. eCollection 2025.
3
Old versus new: upstream and downstream of promyelocytic leukemia zinc finger protein.

本文引用的文献

1
Overexpression of laminin-5 gamma-2 promotes tumorigenesis of pancreatic ductal adenocarcinoma through EGFR/ERK1/2/AKT/mTOR cascade.层粘连蛋白-5γ-2 的过表达通过 EGFR/ERK1/2/AKT/mTOR 级联促进胰腺导管腺癌的肿瘤发生。
Cell Mol Life Sci. 2022 Jun 14;79(7):362. doi: 10.1007/s00018-022-04392-1.
2
Implementation of preventive and predictive BRCA testing in patients with breast, ovarian, pancreatic, and prostate cancer: a position paper of Italian Scientific Societies.BRCA 检测在乳腺癌、卵巢癌、胰腺癌和前列腺癌患者中预防和预测的实施：意大利科学协会的立场文件。
ESMO Open. 2022 Jun;7(3):100459. doi: 10.1016/j.esmoop.2022.100459. Epub 2022 May 19.
3
旧与新：早幼粒细胞白血病锌指蛋白的上游和下游
Cancer Gene Ther. 2025 May 10. doi: 10.1038/s41417-025-00912-w.
4
Machine learning and bioinformatics analysis of diagnostic biomarkers associated with the occurrence and development of lung adenocarcinoma.机器学习和生物信息学分析与肺腺癌发生发展相关的诊断生物标志物。
PeerJ. 2024 Jul 23;12:e17746. doi: 10.7717/peerj.17746. eCollection 2024.
Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles.
上皮间质转化通过改变细胞外囊泡中的 miR-200 水平影响结直肠癌成纤维细胞表型。
J Extracell Vesicles. 2022 May;11(5):e12226. doi: 10.1002/jev2.12226.
4
MiR-26b-5p in small extracellular vesicles derived from dying tumor cells after irradiation enhances the metastasis promoting microenvironment in esophageal squamous cell carcinoma.照射后源自死亡肿瘤细胞的小细胞外囊泡中的 miR-26b-5p 增强了食管鳞癌细胞转移促进的微环境。
Cancer Lett. 2022 Aug 10;541:215746. doi: 10.1016/j.canlet.2022.215746. Epub 2022 May 17.
5
Long noncoding RNAs (lncRNAs) in pancreatic cancer progression.长链非编码 RNA 在胰腺癌进展中的作用。
Drug Discov Today. 2022 Aug;27(8):2181-2198. doi: 10.1016/j.drudis.2022.05.012. Epub 2022 May 16.
6
Tumor immune-gene expression profiles and peripheral immune phenotypes associated with clinical outcomes of locally advanced pancreatic cancer following FOLFIRINOX.FOLFIRINOX 治疗后局部晚期胰腺癌与临床结局相关的肿瘤免疫基因表达谱和外周免疫表型。
ESMO Open. 2022 Jun;7(3):100484. doi: 10.1016/j.esmoop.2022.100484. Epub 2022 May 13.
7
Oncogenic Kras-Mediated Cytokine CCL15 Regulates Pancreatic Cancer Cell Migration and Invasion through ROS.致癌性Kras介导的细胞因子CCL15通过活性氧调节胰腺癌细胞的迁移和侵袭。
Cancers (Basel). 2022 Apr 26;14(9):2153. doi: 10.3390/cancers14092153.
8
Can Surgical Resection of Metastatic Lesions Be Beneficial to Pancreatic Ductal Adenocarcinoma Patients with Isolated Lung Metastasis?手术切除转移性病灶对孤立性肺转移的胰腺导管腺癌患者有益吗？
Cancers (Basel). 2022 Apr 20;14(9):2067. doi: 10.3390/cancers14092067.
9
Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through Long Non-Coding RNA Expression.gp130介导的STAT3激活通过长链非编码RNA表达促进胰腺癌的侵袭性。
Cancers (Basel). 2022 Apr 19;14(9):2055. doi: 10.3390/cancers14092055.
10
LncRNA-MALAT1 Regulates Cancer Glucose Metabolism in Prostate Cancer via MYBL2/mTOR Axis.长链非编码 RNA-MALAT1 通过 MYBL2/mTOR 轴调控前列腺癌中的肿瘤葡萄糖代谢。
Oxid Med Cell Longev. 2022 May 2;2022:8693259. doi: 10.1155/2022/8693259. eCollection 2022.